Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease

被引:20
作者
Cai, Yu [1 ]
Yang, Lu [1 ]
Niu, Fang [1 ]
Liao, Ke [1 ]
Buch, Shilpa [1 ]
机构
[1] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, 985880 Nebraska Med Ctr,DRC 8024, Omaha, NE 68198 USA
来源
SIGMA RECEPTORS: THEIR ROLE IN DISEASE AND AS THERAPEUTIC TARGETS | 2017年 / 964卷
关键词
Sigma-1 receptor (Sig-1R); Alzheimer Disease (AD); Parkinson Disease (PD); Amyotrophic Lateral Sclerosis (ALS); Huntington Disease (HD); Cocaine; AMYOTROPHIC-LATERAL-SCLEROSIS; ENDOPLASMIC-RETICULUM STRESS; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MOUSE MODEL; COGNITIVE IMPAIRMENT; NEURON DISEASE; BINDING-SITES; CELL-SURVIVAL;
D O I
10.1007/978-3-319-50174-1_12
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Sigma-1 receptors (Sig-1R) are recognized as a unique class of non-G protein-coupled intracellular protein. Sig-1R binds to its ligand such as cocaine, resulting in dissociation of Sig-1R from mitochondrion--associated ER membrane (MAM) to the endoplasmic reticulum (ER), plasma membrane, and nuclear membrane, regulating function of various proteins. Sig-1R has diverse roles in both physiological as well as in pathogenic processes. The disruption of Sig-1R pathways has been implicated as causative mechanism(s) in the development of both neurodegenerative disorders such as Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington Disease (HD). Additionally, the interaction of cocaine and Sig-1R has more recently been implicated in potentiating the pathogenesis of HIV-associated neurocognitive disorders (HAND) through impairment of blood-brain barrier (BBB), microglial activation and astrogliosis. On the other hand, restoration of Sig-1R homeostasis has been shown to exert neuroprotective effects. In this review, we provide an overview of how Sig-1R plays a role in the pathogenesis of neurodegenerative disorders and cocaine and implications for future development of therapeutic strategies.
引用
收藏
页码:163 / 175
页数:13
相关论文
共 92 条
[1]  
Abuse S, 2012, NSDUH SERIES H, V44, P12
[2]   Cognitive impairment, retention and abstinence among cocaine abusers in cognitive-behavioral treatment [J].
Aharonovich, E ;
Nunes, E ;
Hasin, D .
DRUG AND ALCOHOL DEPENDENCE, 2003, 71 (02) :207-211
[3]   A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis [J].
Al-Saif, Amr ;
Al-Mohanna, Futwan ;
Bohlega, Saeed .
ANNALS OF NEUROLOGY, 2011, 70 (06) :913-919
[4]   A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy [J].
Atwal, Randy Singh ;
Truant, Ray .
AUTOPHAGY, 2008, 4 (01) :91-93
[5]   Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity [J].
Atwal, Randy Singh ;
Xia, Jianrun ;
Pinchev, Deborah ;
Taylor, Jillian ;
Epand, Richard M. ;
Truant, Ray .
HUMAN MOLECULAR GENETICS, 2007, 16 (21) :2600-2615
[6]   The blood-brain barrier: an overview - Structure, regulation, and clinical implications [J].
Ballabh, P ;
Braun, A ;
Nedergaard, M .
NEUROBIOLOGY OF DISEASE, 2004, 16 (01) :1-13
[7]   Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-β25-35 [J].
Behensky, Adam A. ;
Yasny, Ilya E. ;
Shuster, Alexander M. ;
Seredenin, Sergei B. ;
Petrov, Andrey V. ;
Cuevas, Javier .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2013, 347 (02) :458-467
[8]   Afobazole Activation of σ-1 Receptors Modulates Neuronal Responses to Amyloid-β25-35 [J].
Behensky, Adam A. ;
Yasny, Ilya E. ;
Shuster, Alexander M. ;
Seredenin, Sergei B. ;
Petrov, Andrey V. ;
Cuevas, Javier .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2013, 347 (02) :468-477
[9]   Genetics of Alzheimer Disease [J].
Bekris, Lynn M. ;
Yu, Chang-En ;
Bird, Thomas D. ;
Tsuang, Debby W. .
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2010, 23 (04) :213-227
[10]   ALS:: A disease of motor neurons and their nonneuronal neighbors [J].
Boillee, Sverine ;
Vande Velde, Christine ;
Cleveland, Don W. .
NEURON, 2006, 52 (01) :39-59