First regioselective C-2 lithiation of 3-and 4-chloropyridines

被引：2

作者：

Choppin, S ^{[1
]}

Gros, P ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Nancy 1, Fac Sci, CNRS, UMR UHP 7565, F-54506 Vandoeuvre Les Nancy, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 2001卷 / 03期

关键词：

chloropyridines; lithiation; regioselectivity; complexation;

D O I：

10.1002/1099-0690(200102)2001:3<603::AID-EJOC603>3.0.CO;2-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lilhiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.

引用

页码：603 / 606

页数：4

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