First regioselective C-2 lithiation of 3-and 4-chloropyridines

被引：2
|
作者：
Choppin, S [1 ]
Gros, P [1 ]
Fort, Y [1 ]
机构：
[1] Univ Nancy 1, Fac Sci, CNRS, UMR UHP 7565, F-54506 Vandoeuvre Les Nancy, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 2001卷 / 03期
关键词：
chloropyridines; lithiation; regioselectivity; complexation;
D O I：
10.1002/1099-0690(200102)2001:3<603::AID-EJOC603>3.0.CO;2-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lilhiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.
引用
收藏
页码：603 / 606
页数：4
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