Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses

被引：104

作者：

Florescu, Diana F. ^{[1
,2
]}

Keck, Megan A. ^{[3
]}

机构：

[1] Univ Nebraska Med Ctr, Transplant Infect Dis Program, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Transplant Surg Div, Omaha, NE 68198 USA

[3] Nebraska Med Ctr, Dept Pharmaceut & Nutr Care, Omaha, NE USA

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2014年 / 12卷 / 10期

关键词：

adenovirus; BK virus; Brincidofovir; CMX001; cytomegalovirus; dsDNA virus; JC virus; molluscum; orthopoxvirus; vaccinia virus; REPLICATION IN-VITRO; POLYOMAVIRUS BK REPLICATION; CYTOMEGALOVIRUS-INFECTION; CYCLIC CIDOFOVIR; HEXADECYLOXYPROPYL-CIDOFOVIR; ALKOXYALKYL ESTERS; LIPID ESTERS; SMALLPOX; MICE; DNA;

D O I：

10.1586/14787210.2014.948847

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate. The lipid conjugation results in oral bioavailability, higher intracellular concentrations of active drug, lower plasma concentrations of cidofovir and increased antiviral potency against dsDNA viruses.

引用

页码：1171 / 1178

页数：8

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