Mapping Quantitative Trait Loci (QTL) in sheep. III. QTL for carcass composition traits derived from CT scans and aligned with a meta-assembly for sheep and cattle carcass QTL

被引：42

作者：

Cavanagh, Colin R. ^{[1
,2
]}

Jonas, Elisabeth ^{[1
]}

Hobbs, Matthew ^{[1
]}

Thomson, Peter C. ^{[1
]}

Tammen, Imke ^{[1
]}

Raadsma, Herman W. ^{[1
]}

机构：

[1] Univ Sydney, Fac Vet Sci, ReproGen Anim Biosci Grp, Camden, NSW 2570, Australia

[2] CSIRO Plant Ind, Food Futures Natl Res Flagship, Canberra, ACT, Australia

来源：

GENETICS SELECTION EVOLUTION | 2010年 / 42卷

关键词：

GROWTH-HORMONE RECEPTOR; POSITIONAL CANDIDATE GENES; MEAT QUALITY TRAITS; PARTIAL GENOME SCAN; JAPANESE BLACK; COMPUTER-TOMOGRAPHY; VIRTUAL DISSECTION; FEED-EFFICIENCY; COMMERCIAL LINE; IDENTIFICATION;

D O I：

10.1186/1297-9686-42-36

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

An (Awassi x Merino) x Merino single-sire backcross family with 165 male offspring was used to map quantitative trait loci (QTL) for body composition traits on a framework map of 189 microsatellite loci across all autosomes. Two cohorts were created from the experimental progeny to represent alternative maturity classes for body composition assessment. Animals were raised under paddock conditions prior to entering the feedlot for a 90-day fattening phase. Body composition traits were derived in vivo at the end of the experiment prior to slaughter at 2 (cohort 1) and 3.5 (cohort 2) years of age, using computed tomography. Image analysis was used to gain accurate predictions for 13 traits describing major fat depots, lean muscle, bone, body proportions and body weight which were used for single-and two-QTL mapping analysis. Using a maximum-likelihood approach, three highly significant (LOD >= 3), 15 significant (LOD >= 2), and 11 suggestive QTL (1.7 <= LOD < 2) were detected on eleven chromosomes. Regression analysis confirmed 28 of these QTL and an additional 17 suggestive (P < 0.1) and two significant (P < 0.05) QTL were identified using this method. QTL with pleiotropic effects for two or more tissues were identified on chromosomes 1, 6, 10, 14, 16 and 23. No tissue-specific QTL were identified. A meta-assembly of ovine QTL for carcass traits from this study and public domain sources was performed and compared with a corresponding bovine meta-assembly. The assembly demonstrated QTL with effects on carcass composition in homologous regions on OAR1, 2, 6 and 21.

引用

页数：14

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