Miniature time-of-flight mass spectrometer

被引：3

作者：

McLoughlin, MP ^{[1
]}

Anderson, CW ^{[1
]}

Bryden, WA ^{[1
]}

Carlson, MA ^{[1
]}

Ecelberger, SA ^{[1
]}

Ko, HW ^{[1
]}

机构：

[1] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA

来源：

BIOMEDICAL SENSING AND IMAGING TECHNOLOGIES, PROCEEDINGS OF | 1998年 / 3253卷

关键词：

mass spectrometry; time of flight; biomedical; biological;

D O I：

10.1117/12.308045

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The Johns Hopkins University Applied Physics Laboratory (JHU/APL) is designing, fabricating and testing a small, high resolution, time-of-flight mass spectrometer (TOFMS) suitable for biomedical applications requiring lightweight, low-powered and portable instrumentation. This instrument can be used to identify solids, liquids and gases of both chemical and biological origins to quantify the habitat environment and support biomedical research and medical care. The virtue of the JHU/APL TOFMS technology presented here, resides in the promise for a small (less than one cubic ft.), lightweight (less than 5 kg), low power (less than 50 watts), device that can be used continuously with advanced signal processing diagnostics. To date, JHU/APL has demonstrated mass capability beyond 10,000 Atomic Mass Units (AMU) in a very small, low power prototype for biological analysis. The JHU/APL approach, described in this paper, is to design the instrument for both wide mass range and fine mass resolution by the use of electronic control in a tandem mass spectrometer instrument. In this paper we will outline the principle behind the operation of the APL's miniaturized TOFMS system and present examples of the analysis of chemical and biological substances. In addition, we will also describe a novel method for the collection of airborne particles for TOFMS analysis suitable for automated collection and analysis applications.

引用

页码：155 / 164

页数：10

共 50 条

[41] Hyperthermal surface ionization in a time-of-flight mass spectrometer
Weickhardt, C
Draack, L
Grotemeyer, J
EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2000, 6 (04) : 319 - 323
[42] TOFI: AN ISOCHRONOUS TIME-OF-FLIGHT MASS SPECTROMETER.
Wollnik, H.
Wouters, J.M.
Vieira, D.J.
Nuclear instruments and methods in physics research, 1986, A258 (03): : 331 - 334
[43] Aerosol MALDI with a reflectron time-of-flight mass spectrometer
Fei, X
Wei, G
Murray, KK
ANALYTICAL CHEMISTRY, 1996, 68 (07) : 1143 - 1147
[44] RESOLUTION IN THE LINEAR TIME-OF-FLIGHT MASS-SPECTROMETER
OPSAL, RB
OWENS, KG
REILLY, JP
ANALYTICAL CHEMISTRY, 1985, 57 (09) : 1884 - 1889
[45] DUAL TIME-OF-FLIGHT MASS SPECTROMETER FOR PLASMA ANALYSIS
ALINOVSKII, NI
INSTRUMENTS AND EXPERIMENTAL TECHNIQUES-USSR, 1969, (03): : 781 - +
[46] DEVELOPMENT OF TIME-OF-FLIGHT MASS-SPECTROMETER SYSTEMS
WOLLNIK, H
ANALYTICAL INSTRUMENTATION, 1987, 16 (01): : 15 - 29
[47] Simulation of a miniature, low-power time-of-flight mass spectrometer for in situ analysis of planetary atmospheres
King, Todd. T.
Getty, Stephanie A.
Roman, Patrick A.
Herrero, Federico A.
Jones, Hollis H.
Kahle, Duncan M.
Lynch, Bernard
Suarez, George
Brinckerhoff, William B.
Mahaffy, Paul R.
MICRO (MEMS) AND NANOTECHNOLOGIES FOR SPACE, DEFENSE, AND SECURITY II, 2008, 6959
[48] Compact analyzer for a laser time-of-flight mass spectrometer
Karpov, Alexander V.
Spakhov, Alexander V.
Sysoev, Alexander A.
EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2015, 21 (06) : 823 - 827
[49] Fabrication of a novel micro time-of-flight mass spectrometer
Yoon, HJ
Kim, JH
Choi, ES
Yang, SS
Jung, KW
SENSORS AND ACTUATORS A-PHYSICAL, 2002, 97-8 : 441 - 447
[50] TIME-OF-FLIGHT MASS-SPECTROMETER FOR IMPULSE FACILITIES
SKINNER, KA
STALKER, RJ
AIAA JOURNAL, 1994, 32 (11) : 2325 - 2328

← 1 2 3 4 5 →