Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

被引：48

作者：

Jung, Hoe-Yune ^{[1
,5
,6
]}

Lee, Dongyeop ^{[2
]}

Ryu, Hye Guk ^{[2
]}

Choi, Bo-Hwa ^{[6
]}

Go, Younghoon ^{[8
,10
]}

Lee, Namgyu ^{[2
,11
]}

Lee, Dohyun ^{[2
]}

Son, Heehwa G. ^{[2
]}

Jeon, Jongsu ^{[1
,5
]}

Kim, Seong-Hoon ^{[2
]}

Yoon, Jong Hyuk ^{[2
]}

Park, Seon-Min ^{[6
,7
]}

Lee, Seung-Jae V. ^{[1
,2
,3
,4
]}

Lee, In-Kyu ^{[8
]}

Choi, Kwan Yong ^{[1
,2
]}

Ryu, Sung Ho ^{[1
,2
]}

Nohara, Kazunari ^{[9
]}

Yoo, Seung-Hee ^{[9
]}

Chen, Zheng ^{[9
]}

Kim, Kyong-Tai ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Integrat Biosci & Biotechnol, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea

[2] Pohang Univ Sci & Technol POSTECH, Dept Life Sci, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea

[3] Pohang Univ Sci & Technol POSTECH, Informat Technol Convergence Engn, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea

[4] Pohang Univ Sci & Technol POSTECH, Sch Interdisciplinary Biosci & Bioengn, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea

[5] NovMetaPharma Co Ltd, R&D Ctr, 394 Jigok Ro, Pohang 37668, Gyeongbuk, South Korea

[6] Pohang Technopk, Adv Bio Convergence Ctr, 394 Jigok Ro, Pohang 37668, Gyeongbuk, South Korea

[7] Kyungpook Natl Univ, Dept Vet Med, Daegu 41566, South Korea

[8] Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41407, South Korea

[9] Univ Texas Hlth Sci Ctr Houston, Dept Biochem & Mol Biol, 6431 Fannin St, Houston, TX 77030 USA

[10] KIOM, Korean Med KM Applicat Ctr, Daegu 41062, South Korea

[11] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

新加坡国家研究基金会;

关键词：

LIFE-SPAN EXTENSION; CAENORHABDITIS-ELEGANS; INSULIN-RESISTANCE; OXIDATIVE-PHOSPHORYLATION; METABOLIC DISEASE; IN-VIVO; MUSCLE; TRANSCRIPTION; COACTIVATOR; RESVERATROL;

D O I：

10.1038/s41598-017-05303-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1 alpha acetylation through SIRT1 activation. Furthermore, myricetin significantly improved the healthspan and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans. These results demonstrate that myricetin enhances mitochondrial activity, possibly by activating PGC-1 alpha and SIRT1, to improve physical endurance, strongly suggesting myricetin as a mitochondria-activating agent.

引用

页数：10

共 45 条

[1] SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD [J].