Synthesis, characterization and in vitro antimicrobial studies of new 2,3-disubstituted quinazolin-4(3H) ones of 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid

被引：0
作者：
Patel, Navin B. [1 ]
Shaikh, Asif R. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 07期
关键词：
Antibacterial; antifungal; benzoxazinone; 1,3-oxazole; quinazolinone; BIOLOGICAL EVALUATION; AGENTS; INHIBITORS; ANTIBACTERIAL; DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-[2-(2,6-Dichlorophenyl)amino]phenylmethyl-3-{4-[(substituted phenyl)amino]-1,3-oxazol-2-yl}-]-6-bromoquinazolin-4(3H)ones 5a-o have been synthesized from the lead molecule 2-[(2,6-dichlorophenyl)amino]phenyl acetic acid 1, via carboxamide 4. Compound 4 on cyclization with substituted phenyl acetamicle a-o give desired compounds 5a-o. The title compounds have been characterized by elemental analysis, IR, H-1 NMR and C-13 NMR spectral data. All the compounds have been screened or antibacterial and antifungal activity.
引用
收藏
页码：929 / 936
页数：8
相关论文
共 50 条
  • [31] 3-(2-Hydroxyethyl)-2-(p-tolylamino)-quinazolin-4(3H)-one
    Zhang, Gui-Fu
    Ma, Zuan
    Yang, Xu-Hong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O34 - U1575
  • [32] Efficient Synthesis of RuO2 Nanoparticle with excellent activity for one-pot Synthesis of 2,3-disubstituted quinazolin-4(1H)-ones
    Raghu, M. S.
    Prasad, K. N. N.
    Jayanna, B. K.
    Kumar, C. B. Pradeep
    Kumar, K. Yogesh
    Prashanth, M. K.
    VIETNAM JOURNAL OF CHEMISTRY, 2019, 57 (05) : 585 - 594
  • [33] Vibrational spectra and computational study of 3-amino-2-phenyl quinazolin-4(3H)-one
    Panicker, C. Yohannan
    Varghese, Hema Tresa
    Ambujakshan, K. R.
    Mathew, Samuel
    Ganguli, Subarna
    Nanda, Ashis Kumar
    Van Alsenoy, Christian
    Mary, Y. Sheena
    JOURNAL OF MOLECULAR STRUCTURE, 2010, 963 (2-3) : 137 - 144
  • [34] Synthesis of Novel 2-(Substituted amino)alkylthiopyrimidin-4(3H)-ones as Potential Antimicrobial Agents
    Attia, Mohamed I.
    El-Emam, Ali A.
    Al-Turkistani, Abdulghafoor A.
    Kansoh, Amany L.
    El-Brollosy, Nasser R.
    MOLECULES, 2014, 19 (01): : 279 - 290
  • [35] Total synthesis of penipanoid C, 2-(4-hydroxybenzyl)quinazolin-4 (3H)-one and NU1025
    Ghosh, Suman Kr
    Nagarajan, Rajagopal
    TETRAHEDRON LETTERS, 2016, 57 (38) : 4277 - 4279
  • [36] Synthesis and Evaluation of Antioxidant Properties of 2-Substituted Quinazolin-4(3H)-ones
    Mravljak, Janez
    Slavec, Lara
    Hrast, Martina
    Sova, Matej
    MOLECULES, 2021, 26 (21):
  • [37] Chalcogenation/pyrrolo(pyrido)annulation of 2-(3-butenyl) quinazolin-4(3H)-ones by arylsulfenyl(selenyl) chlorides
    Vaskevych, Alla I. I.
    Savinchuk, Nataliia O. O.
    Vaskevych, Ruslan I. I.
    Rusanov, Eduard B. B.
    Vovk, Mykhailo V.
    TETRAHEDRON, 2022, 111
  • [38] 2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism
    Wang, Rui
    Chai, Wei-Ming
    Yang, Qin
    Wei, Man-Kun
    Peng, Yiyuan
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (19) : 4620 - 4625
  • [39] Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems
    Zhoujin, Yunping
    Li, Yuping
    Zhang, Mingtao
    Parkin, Sean
    Guo, Ju
    Li, Tonglei
    Yu, Faquan
    Long, Sihui
    CRYSTENGCOMM, 2022, 24 (03) : 681 - 690
  • [40] New 6-bromo-2-methyl-3-(Substituted Phenyl)-(3H)-quinazolin-4-Ones with Antimicrobial and Antiinflammatory activities
    Murti, Y.
    Singh, A. K.
    Pathak, D.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 73 (03) : 333 - 337
12345