Synthesis, characterization and in vitro antimicrobial studies of new 2,3-disubstituted quinazolin-4(3H) ones of 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid

被引：0
|
作者：
Patel, Navin B. [1 ]
Shaikh, Asif R. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 07期
关键词：
Antibacterial; antifungal; benzoxazinone; 1,3-oxazole; quinazolinone; BIOLOGICAL EVALUATION; AGENTS; INHIBITORS; ANTIBACTERIAL; DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-[2-(2,6-Dichlorophenyl)amino]phenylmethyl-3-{4-[(substituted phenyl)amino]-1,3-oxazol-2-yl}-]-6-bromoquinazolin-4(3H)ones 5a-o have been synthesized from the lead molecule 2-[(2,6-dichlorophenyl)amino]phenyl acetic acid 1, via carboxamide 4. Compound 4 on cyclization with substituted phenyl acetamicle a-o give desired compounds 5a-o. The title compounds have been characterized by elemental analysis, IR, H-1 NMR and C-13 NMR spectral data. All the compounds have been screened or antibacterial and antifungal activity.
引用
收藏
页码：929 / 936
页数：8
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