Synthesis, characterization and in vitro antimicrobial studies of new 2,3-disubstituted quinazolin-4(3H) ones of 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid

被引：0

作者：

Patel, Navin B. ^{[1
]}

Shaikh, Asif R. ^{[1
]}

机构：

[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 07期

关键词：

Antibacterial; antifungal; benzoxazinone; 1,3-oxazole; quinazolinone; BIOLOGICAL EVALUATION; AGENTS; INHIBITORS; ANTIBACTERIAL; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-[2-(2,6-Dichlorophenyl)amino]phenylmethyl-3-{4-[(substituted phenyl)amino]-1,3-oxazol-2-yl}-]-6-bromoquinazolin-4(3H)ones 5a-o have been synthesized from the lead molecule 2-[(2,6-dichlorophenyl)amino]phenyl acetic acid 1, via carboxamide 4. Compound 4 on cyclization with substituted phenyl acetamicle a-o give desired compounds 5a-o. The title compounds have been characterized by elemental analysis, IR, H-1 NMR and C-13 NMR spectral data. All the compounds have been screened or antibacterial and antifungal activity.

引用

页码：929 / 936

页数：8

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