Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells

被引:363
作者
Alvaro, T
Lejeune, M
Salvadó, MT
Bosch, R
García, JF
Jaén, J
Banham, AH
Roncador, G
Montalbán, C
Piris, MA
机构
[1] Hosp Tortosa Verge Cinta, Dept Pathol, Tortosa 43500, Spain
[2] Hosp Ramon y Cajal, Mol Pathol Programme, E-28034 Madrid, Spain
[3] Hosp Ramon y Cajal, Monoclonal Antibodies Unit, E-28034 Madrid, Spain
[4] Hosp Ramon y Cajal, Ctr Nacl Invest Oncol, E-28034 Madrid, Spain
[5] Hosp Ramon y Cajal, Dept Internal Med, E-28034 Madrid, Spain
[6] John Radcliffe Hosp, Leukaemia Res Fund Immunodiagnost Unit, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England
关键词
D O I
10.1158/1078-0432.CCR-04-1869
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Recent studies of Hodgkin's lymphoma (HL) have suggested that the presence of regulatory T cells in the reactive background may explain the inhibition of the antitumoral host immune response observed in these patients. This study aimed to assess the relevance of regulatory T cells and CTLs present in the background of HL samples in the prognosis of a series of classic HL (cHL) patients. Experimental Design: Expression of granzyme B and TIA-1 (markers for CTL) and FOXP3 (a marker for regulatory T cells) were evaluated independently by immunohistochemistry in tissue microarrays of 257 cHL patients and correlated with patient outcome. Results: The combined influence of the presence of FOXP3(+) and TIA-1(+) cells distinguished three risk groups of patients with 5-year overall survival of 100%, 88%, and 73%. The presence of a small number of FOXP3(+) cells and a high proportion of TIA-1(+) cells in the infiltrate represent an independent prognostic factor that negatively influenced event-free survival and disease-free survival in cHL. Compared with the features at diagnosis, relapsed samples tended to have more TIA-1(+) cells and a lower proportion of FOXP3(+) cells in the reactive background. Conclusions: These data suggest that low infiltration of FOXP3(+) cells in conjunction with high infiltration of TIA-1(+) cells in cHL may represent biological markers predicting an unfavorable outcome. Moreover, the variation of these markers over the course of the disease implies a possible role for them in the progression of HL cases.
引用
收藏
页码:1467 / 1473
页数:7
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