Colorectal cancer screening: Prospects for molecular stool analysis

被引：169
作者：
Davies, RJ
Miller, R
Coleman, N
机构：
[1] MRC, Hutchison MRC Res Ctr, Canc Cell Unit, Cambridge CB2 2XZ, England
[2] Addenbrookes Hosp, Dept Gen Surg, Cambridge CB2 2QQ, England
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 03期
关键词：
D O I：
10.1038/nrc1569
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer is common. As many patients present with advanced disease, an effective screening test would have substantial clinical benefits. Recent progress in understanding the biology of colorectal cancer ( and of cancer cells in general) has led to possible new approaches to screening. In particular, there are prospects of developing tests based on analysis of stool, which promise improved accuracy, safety, affordability and patient compliance.
引用
收藏
页码：199 / 209
页数：11
相关论文
共 108 条
  • [1] Morphometric analysis of the "mucocellular layer" overlying colorectal cancer and normal mucosa: Relevance to exfoliation and stool screening
    Ahlquist, DA
    Harrington, JJ
    Burgart, LJ
    Roche, PC
    [J]. HUMAN PATHOLOGY, 2000, 31 (01) : 51 - 57
  • [2] Colorectal cancer screening by detection of altered human DNA in stool: Feasibility of a multitarget assay panel
    Ahlquist, DA
    Skoletsky, JE
    Boynton, KA
    Harrington, JJ
    Mahoney, DW
    Pierceall, WE
    Thibodeau, SN
    Shuber, AP
    [J]. GASTROENTEROLOGY, 2000, 119 (05) : 1219 - 1227
  • [3] FECAL BLOOD-LEVELS IN HEALTH AND DISEASE - A STUDY USING HEMOQUANT
    AHLQUIST, DA
    MCGILL, DB
    SCHWARTZ, S
    TAYLOR, WF
    OWEN, RA
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (22) : 1422 - 1428
  • [4] Ahlquist DA, 2002, GASTROENTEROLOGY, V122, pA40
  • [5] Stool screening for colorectal cancer: evolution from occult blood to molecular markers
    Ahlquist, DA
    Shuber, AP
    [J]. CLINICA CHIMICA ACTA, 2002, 315 (1-2) : 157 - 168
  • [6] AHLQUIST DA, 1989, CANCER, V63, P1826
  • [7] Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study
    Andreyev, HJN
    Norman, AR
    Cunningham, D
    Oates, JR
    Clarke, PA
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (09) : 675 - 684
  • [8] Single flexible sigmoidoscopy screening to prevent colorectal cancer: baseline findings of a UK multicentre randomised trial
    Atkin, WS
    Cook, CF
    Cuzick, J
    Edwards, R
    Northover, JMA
    Wardle, J
    [J]. LANCET, 2002, 359 (9314) : 1291 - 1300
  • [9] BADER GM, 1952, CANCER, V5, P307, DOI 10.1002/1097-0142(195203)5:2<307::AID-CNCR2820050217>3.0.CO
  • [10] 2-3
12345678910