Intramolecular alkyne hydroalkoxylation and hydroamination catalyzed by iridium hydrides

被引：225
作者：
Li, XW [1 ]
Chianese, AR [1 ]
Vogel, T [1 ]
Crabtree, RH [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 24期
关键词：
D O I：
10.1021/ol052186i
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Iridium(III) hydrides prove to be air-stable active catalysts for intramolecular hydroalkoxylation and hydroamination of internal alkynes with proximate nucleophiles. The cyclization follows highly selective 6-endo-dig regiochemistry when regioselectivity is an issue.
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页码：5437 / 5440
页数：4
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