Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis

被引：29

作者：

Madaiah, Malavalli ^{[1
]}

Prashanth, Maralekere K. ^{[2
]}

Revanasiddappa, Hosakere D. ^{[1
]}

Veeresh, Bantal ^{[3
]}

机构：

[1] Univ Mysore, Dept Chem, Mysore 570006, Karnataka, India

[2] BNM Inst Technol, Dept Chem, Bangalore 560070, Karnataka, India

[3] G Pullareddy Coll Pharm, Dept Pharmacol, Hyderabad 580028, Andhra Pradesh, India

来源：

NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 11期

关键词：

DRUG; ANTITUBERCULOSIS; RESISTANCE;

D O I：

10.1039/c6nj02069k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/ urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacological activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg(-1) body weight.

引用

页码：9194 / 9204

页数：11

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