Increased expression of Rab coupling protein in squamous cell carcinoma of the head and neck and its clinical significance

被引：14

作者：

Dai, Yaozhang ^{[1
,2
]}

Liu, Yong ^{[1
]}

Huang, Donghai ^{[1
]}

Yu, Changyun ^{[1
]}

Cai, Gengming ^{[1
]}

Pi, Leiming ^{[1
]}

Ren, Caiping ^{[3
]}

Chen, Georgia Z. ^{[4
]}

Tian, Yongquan ^{[1
]}

Zhang, Xin ^{[1
]}

机构：

[1] Cent S Univ, Dept Otolaryngol Head & Neck Surg, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Otolaryngol, Zhengzhou 450052, Henan, Peoples R China

[3] Cent S Univ, Canc Res Inst, Changsha 410008, Hunan, Peoples R China

[4] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA 30322 USA

来源：

ONCOLOGY LETTERS | 2012年 / 3卷 / 06期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

squamous cell carcinoma of the head and neck; Rab coupling protein; prognosis; metastasis; CANCER; TRANSPORT; POLARITY; GTPASES;

D O I：

10.3892/ol.2012.652

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of Rab coupling protein (RCP) has not been previously investigated in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to explore RCP protein expression and its clinicopathological significance in SCCHN. RCP protein expression in 95 SCCHN samples, 18 vocal nodule epithelia and 16 leukoplakia epithelia samples was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patient outcome. Our data indicated that vocal nodule epithelia, leukoplakia epithelia and SCCHN showed a gradual increase in the expression of RCP protein. RCP overexpression was significantly associated with T classification, clinical staging, lymph node metastasis and recurrence. Survival analysis revealed that a high RCP expression was significantly correlated with shorter overall survival and disease-free survival. In conclusion, RCP protein may contribute to the malignant progression of SCCHN, and serves as a novel prognostic marker in patients with SCCHN.

引用

页码：1231 / 1236

页数：6

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