Clinical and molecular epidemiological characterization of extensively drug-resistant Acinetobacter baumannii in patients with liver disease

被引：0
作者：
Yu, Yanhua [1 ]
Chen, Ming [2 ]
Lou, Jinli [2 ]
Su, Jianrong [1 ]
机构：
[1] Capital Med Univ, Beijing Friendship Hosp, Clin Lab Ctr, 95 Yongan Rd, Beijing 100050, Peoples R China
[2] Capital Med Univ, Beijing Youan Hosp, Clin Lab Ctr, Beijing, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 07期
关键词：
Acinetobacter baumannii; extensively drug-resistant; multilocus sequence typing (MLST); INFECTION; HOSPITALS; SPREAD;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The global prevalence of extensively drug-resistant (XDR) Acinetobacter baumannii (A. baumannii) has become a healthcare-associated problem. We aimed to investigate the molecular characteristics of XDR A. baumannii in patients with liver disease. Fifty-nine non-duplicated XDR A. baumannii from our hospital patients with liver disease were collected in China between December 2009 and October 2012. All isolates was performed by antibiotic susceptibility test and multilocus sequence typing. Resistance genes were detected by PCR. All isolates were resistance to common antibiotics except polymyxin B. The OXA-23, OXA-51, GIM and OXA-58 genes were prevalent in the XDR A. baumannii. Three clones were widespread in 59 isolates: ST381 (11 isolates, 18.6%), ST425 (11 isolates, 18.6%) and ST492 (12 isolates, 20.3%). We explored the drug resistance and molecular typing of XDR A. baumannii isolates from our hospital. The major clones, ST381, ST425 and ST492, have disseminated in our hospital patients with liver disease.
引用
收藏
页码：13127 / 13134
页数：8
相关论文
共 50 条
  • [21] In vitro synergistic activity of the sulbactam/avibactam combination against extensively drug-resistant Acinetobacter baumannii
    Rodriguez, Carlos Hernan
    Brune, Adriana
    Nastro, Marcela
    Vay, Carlos
    Famiglietti, Angela
    JOURNAL OF MEDICAL MICROBIOLOGY, 2020, 69 (07) : 928 - 931
  • [22] Whole-Genome-Sequence-Based Characterization of Extensively Drug-Resistant Acinetobacter baumannii Hospital Outbreak
    Makke, Ghiwa
    Bitar, Ibrahim
    Salloum, Tamara
    Panossian, Balig
    Alousi, Sahar
    Arabaghian, Harout
    Medvecky, Matej
    Hrabak, Jaroslav
    Merheb-Ghoussoub, Samar
    Tokajian, Sima
    MSPHERE, 2020, 5 (01)
  • [23] High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013-2019
    Barrientos-Yong, Rodrigo Samuel
    Hinojosa-Salas, Bryan Andrei
    Salas-Ponce, Percy Genaro
    Angles, Eddie
    Ruiz, Joaquim
    Pons, Maria J.
    TROPICAL DOCTOR, 2023, 53 (02) : 248 - 255
  • [24] Isolation and characterization of Siphoviridae phage infecting extensively drug-resistant Acinetobacter baumannii and evaluation of therapeutic efficacy in vitro and in vivo
    Wintachai, Phitchayapak
    Naknaen, Ampapan
    Pomwised, Rattanaruji
    Voravuthikunchai, Supayang Piyawan
    Smith, Duncan R.
    JOURNAL OF MEDICAL MICROBIOLOGY, 2019, 68 (07) : 1096 - 1108
  • [25] Clinical Epidemiology, Treatment, and Prognostic Factors of Hospital-Acquired Pneumonia Caused by the Extensively Drug-Resistant Acinetobacter Baumannii
    Fang, Changquan
    Xu, Limin
    Li, Yujun
    Wei, Shuquan
    Zhao, Zhuxiang
    Zhao, Ziwen
    CLINICAL LABORATORY, 2023, 69 (01) : 84 - 91
  • [26] In Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii
    Park, Gyun Cheol
    Choi, Ji Ae
    Jang, Sook Jin
    Jeong, Seok Hoon
    Kim, Choon-Mee
    Choi, In Sun
    Kang, Seong Ho
    Park, Geon
    Moon, Dae Soo
    ANNALS OF LABORATORY MEDICINE, 2016, 36 (02) : 124 - 130
  • [27] Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant Acinetobacter spp
    Carvalho, A. A.
    Cardoso, L. L.
    Nogueira, H. S.
    Menezes, E. V.
    Xavier, M. A. S.
    Barreto, N. A. P.
    Fernandes, L. F.
    Xavier, A. R. E. O.
    GENETICS AND MOLECULAR RESEARCH, 2016, 15 (03)
  • [28] In Vitro Activities of Novel Antimicrobial Combinations against Extensively Drug-Resistant Acinetobacter baumannii
    Cordoba, J.
    Coronado-Alvarez, N. M.
    Parra, D.
    Parra-Ruiz, J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (12) : 7316 - 7319
  • [29] High frequency of carbapenemase in extensively drug-resistant Acinetobacter baumannii isolates in central Iran
    Abbasi, Elnaz
    van Belkum, Alex
    Ghaznavi-Rad, Ehsanollah
    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2023, 39 (11)
  • [30] The Frequency of Multidrug- Resistance and Extensively Drug-Resistant Acinetobacter Baumannii in West of Iran
    Moghadam, Reza Hatami
    Alvandi, Amir Houshang
    Akbari, Neda
    Jafari, Parvaneh
    Abiri, Ramin
    JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE, 2018, 6 (02): : 112 - 119
12345