Clinical and molecular epidemiological characterization of extensively drug-resistant Acinetobacter baumannii in patients with liver disease

The global prevalence of extensively drug-resistant (XDR) Acinetobacter baumannii (A. baumannii) has become a healthcare-associated problem. We aimed to investigate the molecular characteristics of XDR A. baumannii in patients with liver disease. Fifty-nine non-duplicated XDR A. baumannii from our hospital patients with liver disease were collected in China between December 2009 and October 2012. All isolates was performed by antibiotic susceptibility test and multilocus sequence typing. Resistance genes were detected by PCR. All isolates were resistance to common antibiotics except polymyxin B. The OXA-23, OXA-51, GIM and OXA-58 genes were prevalent in the XDR A. baumannii. Three clones were widespread in 59 isolates: ST381 (11 isolates, 18.6%), ST425 (11 isolates, 18.6%) and ST492 (12 isolates, 20.3%). We explored the drug resistance and molecular typing of XDR A. baumannii isolates from our hospital. The major clones, ST381, ST425 and ST492, have disseminated in our hospital patients with liver disease.