A highly efficient solid-phase synthesis of 1,3-substituted xanthines

被引：15

作者：

He, RJ ^{[1
]}

Lam, YL ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2005年 / 7卷 / 06期

关键词：

D O I：

10.1021/cc050088i

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A first solid-phase route to 1,3-substituted xanthines has been developed using PS-MB-CHO resin. Cyclocondensation of the polymer-bound aminoimidazole with isocyanates followed by alkylation provided 1,3-substituted xanthines in high yields. Libraries of 12 xanthines and 4 thioxanthines were prepared.

引用

页码：916 / 920

页数：5

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