Synthesis and bioactivity of arylaldehyde-[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-thiol acetyl hydrazones

被引：0

作者：

Chen, Jiang ^{[1
]}

Liu, Fang ^{[1
]}

Song, Bao-An ^{[1
]}

Yang, Song ^{[1
]}

Hu, De-Yu ^{[1
]}

Jin, Lin-Hong ^{[1
]}

Chen, Zhuo ^{[1
]}

Xue, Wei ^{[1
]}

机构：

[1] Guizhou Univ, Res & Dev Ctr Fine Chem, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 28卷 / 05期

关键词：

hydrazone derivative; 1,3,4-thiadiazole; synthesis; antifungal activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eight arylaldehyde-[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-acetyl hydrazone derivatives were synthesized with [5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazole-2-thiol as starting material according to substructure link principle, followed by thioetherification, hydrazide reaction and hydrazone reaction. The structures of these compounds were determined by elemental analysis, IR, H-1 NMR, and C-13 NMR spectra. Bioassay of the title compounds indicated that some of them exhibited moderate antifungal activity.

引用

页码：894 / 898

页数：5

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