Ozone treatment ameliorates oil sands process water toxicity to the mammalian immune system

被引：57
作者：
Garcia-Garcia, Erick [1 ]
Ge, Jun Qing [1 ,4 ]
Oladiran, Ayoola [1 ]
Montgomery, Benjamin [1 ]
El-Din, Mohamed Gamal [2 ]
Perez-Estrada, Leonidas C. [2 ]
Stafford, James L. [1 ]
Martin, Jonathan W. [3 ]
Belosevic, Miodrag [1 ]
机构：
[1] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada
[2] Univ Alberta, Dept Civil & Environm Engn, Edmonton, AB T6G 2E9, Canada
[3] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2E9, Canada
[4] Fujian Acad Agr Sci, Inst Biotechnol, Fuzhou 350003, Peoples R China
来源：
WATER RESEARCH | 2011年 / 45卷 / 18期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Advanced oxidation; Ozone; Immunotoxicity; Water remediation; Water purification; Tailing ponds; NAPHTHENIC ACIDS; MASS-SPECTROMETRY; IN-VITRO; OZONATION; BIOREMEDIATION; STRATEGIES; EFFLUENTS; SAMPLES;
D O I：
10.1016/j.watres.2011.08.032
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
We evaluated whether ozonation ameliorated the effects of the organic fraction of oil sands process water (OSPW) on immune functions of mice. Ozonation of OSPW eliminated the capacity of its organic fraction to affect various mouse bone marrow-derived macrophage (BMDM) functions in vitro. These included the production of nitric oxide and the expression of inducible nitric oxide synthase, the production of reactive oxygen intermediates and the expression of NADPH oxidase subunits, phagocytosis, and the expression of pro-inflammatory cytokine genes. Ozone treatment also eliminated the ability of OSPW organic fraction to down-regulate the expression of various pro-inflammatory cytokine and chemokine genes in the liver of mice, one week after oral exposure. We conclude that ozone treatment may be a valuable process for the remediation of large volumes of OSPW. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5849 / 5857
页数：9
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