Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity

被引：79

作者：

Guallar, Maria Pilar ^{[1
,2
,3
,4
]}

Meirino, Rosa ^{[5
]}

Donat-Vargas, Carolina ^{[1
,6
]}

Corral, Octavio ^{[7
]}

Jouve, Nicolas ^{[7
]}

Soriano, Vicente ^{[8
,9
]}

机构：

[1] Univ Autonoma Madrid, Med Sch, Dept Prevent Med Publ Hlth & Microbiol, Madrid, Spain

[2] IdiPAZ, Madrid, Spain

[3] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[4] CEI UAM CSIC, IMDEA Food Inst, Madrid, Spain

[5] Clin Univ Navarra, Oncol Dept, Madrid, Spain

[6] Karolinska Inst, Environm Med Inst IMM, Nutr & Cardiovasc Epidemiol Unit, Stockholm, Sweden

[7] Alcala Univ, Genet Dept, Madrid, Spain

[8] UNIR, Med Ctr, Calle Almansa 101, Madrid 28040, Spain

[9] UNIR, Hlth Sci Sch, Calle Almansa 101, Madrid 28040, Spain

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 97卷

关键词：

coronavirus; COVID-19; inoculum; outbreak; transmission; epidemiology; disease severity;

D O I：

10.1016/j.ijid.2020.06.035

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：290 / 292

页数：3

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