Steroidal regulation of portal arginine-vasopressin levels in aged Fischer 344 rats

被引：2

作者：

Mulchahey, JJ

Kasckow, JW

Plotsky, PM

Hauger, RL

机构：

[1] Vet Affairs Med Ctr, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45267 USA

[3] Univ Cincinnati, Program Neurosci, Cincinnati, OH 45267 USA

[4] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA

[5] Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA

[6] San Diego VAMC, La Jolla, CA 92092 USA

来源：

BRAIN RESEARCH | 1999年 / 822卷 / 1-2期

关键词：

arginine-vasopressin; stress; aging; rat; brain; corticosterone; ACTH; corticotropin-releasing factor;

D O I：

10.1016/S0006-8993(98)01370-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Levels of hypophysial portal arginine-vasopressin (AVP), plasma ACTH and plasma corticosterone (B) were measured in four and 24 month old Fischer 344 rats. Portal levels of AVP were lower in older rats whereas plasma ACTH levels were elevated. Older rats given adrenalectomies with physiologic replacement doses of B exhibited levels of AVP, but not ACTH, which were comparable to that observable in younger rats. The findings suggest that altered AVP, but not ACTH, can be accounted for by higher B levels which are commonly demonstrable in aging rats. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：243 / 245

页数：3

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