Hepatobiliary MR imaging with gadolinium-based contrast agents

被引:119
作者
Frydrychowicz, Alex [2 ]
Lubner, Meghan G.
Brown, Jeffrey J. [3 ]
Merkle, Elmar M. [4 ]
Nagle, Scott K. [5 ]
Rofsky, Neil M. [6 ]
Reeder, Scott B. [1 ,5 ,7 ,8 ]
机构
[1] Univ Wisconsin, Dept Radiol, CSC, Madison, WI 53792 USA
[2] Univ Hosp Schleswig Holstein, Dept Radiol & Nucl Med, Lubeck, Germany
[3] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA
[4] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA
[5] Univ Wisconsin, Dept Med Phys, Madison, WI 53792 USA
[6] Univ Texas SW Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA
[7] Univ Wisconsin, Dept Med, Madison, WI 53792 USA
[8] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53792 USA
基金
美国国家卫生研究院;
关键词
magnetic resonance imaging; liver; biliary; hepatobiliary gadolinium based contrast agents; gadobenate dimeglumine; gadoxetic acid; GD-EOB-DTPA; FOCAL LIVER-LESIONS; GADOXETIC-ACID-DISODIUM; PRIMARY SCLEROSING CHOLANGITIS; MAGNETIC-RESONANCE CHOLANGIOGRAPHY; MULTICENTER PHASE-III; I CLINICAL-EVALUATION; HEPATOCELLULAR-CARCINOMA; GADOBENATE DIMEGLUMINE; NODULAR HYPERPLASIA;
D O I
10.1002/jmri.22833
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The advent of gadolinium-based hepatobiliary contrast agents offers new opportunities for diagnostic magnetic resonance imaging (MRI) and has triggered great interest for innovative imaging approaches to the liver and bile ducts. In this review article we discuss the imaging properties of the two gadolinium-based hepatobiliary contrast agents currently available in the U.S., gadobenate dimeglumine and gadoxetic acid, as well as important pharmacokinetic differences that affect their diagnostic performance. We review potential applications, protocol optimization strategies, as well as diagnostic pitfalls. A variety of illustrative case examples will be used to demonstrate the role of these agents in detection and characterization of liver lesions as well as for imaging the biliary system. Changes in MR protocols geared toward optimizing workflow and imaging quality are also discussed. It is our aim that the information provided in this article will facilitate the optimal utilization of these agents and will stimulate the reader's pursuit of new applications for future benefit. J. Magn. Reson. Imaging 2012;35:492-511. (c) 2011 Wiley Periodicals, Inc.
引用
收藏
页码:492 / 511
页数:20
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