Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients:: A randomized, double-blind, placebo-controlled trial

被引:58
作者
Leaker, Brian R. [3 ]
O'Connor, B. [3 ]
Hansel, Trevor T. [3 ]
Barnes, Peter J. [3 ]
Meng, Lixen [1 ]
Mathur, Vandana S. [2 ]
Lieu, Hsiao D. [2 ]
机构
[1] CV Therapeut, Biostat, Palo Alto, CA 94304 USA
[2] CV Therapeut, Clin Res, Palo Alto, CA 94304 USA
[3] Pulmonol Heart & Lung Ctr, London, England
关键词
reactive airways; spirometry; pulmonary function test; stress test; adenosine receptor;
D O I
10.1016/j.nuclcard.2008.02.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Patients with reactive airways are at risk for adenosine-induced bronchoconstriction, mediated via A(2B) and/or A3 adenosine receptors. Methods and Results. To examine the effects of regadenoson, a selective adenosine A(2A) receptor agonist, on airway resistance, we conducted a randomized, double-blind, placebo-controlled crossover trial in asthmatic patients with a positive adenosine monophosphate challenge test. The mean ratio of the forced expiratory volume in 1 second (FEV1) at each tested time point relative to the baseline FEV1, was significantly higher after treatment with regadenoson compared with placebo from 10 to 60 minutes after treatment. One patient had a substantial but asymptomatic FEV1 reduction (-36.2%) after regadenoson that reversed spontaneously. The most common adverse events with regadenoson were tachycardia (66%), dizziness (53%), headache (45%), and dyspnea (34%). The mean heart rate significantly increased with regadenoson (maximum of +10.4 beats/min) versus placebo. Conclusions. In this pilot safety study of 48 patients with mild or moderate asthma who had bronchial reactivity to adenosine monophosphate, regadenoson was safe and well tolerated.
引用
收藏
页码:329 / 336
页数:8
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