Colorimetric procedure for the microdetermination of the antibilharzial drug praziquantel and its applications to pharmaceutical formulations

被引：14

作者：

Amin, AS ^{[1
]}

Ahmed, IS ^{[1
]}

机构：

[1] Benha Univ, Fac Sci, Dept Chem, Banha, Egypt

来源：

MIKROCHIMICA ACTA | 2001年 / 137卷 / 1-2期

关键词：

colorimetric assay; praziquantel determination; charge transfer complexes; pharmaceutical formulations;

D O I：

10.1007/s006040170025

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A procedure for the colorimetric assay of praziquantel has been developed. The method is based on the formation of charge-transfer complexes with p-chloranil (I), dichloronitrophenol (II), 2,3-dichloro-5,6 dicyano-p-benzoquinone (III), 7,7,8,8-tetracyanoquinodimethane (IV) and tetracyanoethylene (V) as pi -acceptors to give highly coloured species. The coloured products are measured spectrophotometrically at 550, 425, 460, 844 and 393 mn for I, II, III, IV and V, respectively. Optimization of the different reaction conditions is described. The colour system obeyed Beer's law in non-aqueous media in the concentration range 2.0-48 mug ml(-1). It was stable for at least 4.0 h. The detection limit was found to be 0.6 mug ml(-1). Applications of the procedure to the analysis of various pharmaceutical samples gave reproducible and accurate results. Further, the validity of the procedure was confirmed by applying the standard addition technique. The total average recovery was 100.2%.

引用

页码：35 / 40

页数：6

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