Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase

被引：5

作者：

Haas, R

Tsivunchyk, O

Steinbach, K

von Löw, E

Scheibner, K

Hofrichter, M

机构：

[1] Off Environm Invest & Res, D-35037 Marburg, Germany

[2] Grodno State Univ, Yanka Kupala, Grodno 230023, BELARUS

[3] Univ Marburg, Inst Immunol, D-35037 Marburg, Germany

[4] JenaBios GmbH, D-07749 Jena, Germany

[5] Int Grad Sch Zittau, Unit Environm Biotechnol, D-02763 Zittau, Germany

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2004年 / 63卷 / 05期

关键词：

D O I：

10.1007/s00253-003-1453-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fungal manganese peroxidase was found to convert the persistent chemical warfare agent adamsite (phenarsarzin chloride) in a cell-free reaction mixture containing sodium malonate, Mn2+ ions, and reduced glutathione. The organo-arsenical compound disappeared completely within 48 h accompanied by the formation of a more polar metabolite with a clearly modified UV spectrum. Thus, As(III) in the adamsite molecule was oxidized by manganese peroxidase to As(V) which added dioxygen and released chloride.

引用

页码：564 / 566

页数：3

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