Determination of Pindone in Agricultural Products by LC-MS/MS

被引:2
作者
Saito, Shizuka [1 ]
Nemoto, Satoru [1 ]
Matsuda, Rieko [1 ]
机构
[1] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan
来源
FOOD HYGIENE AND SAFETY SCIENCE | 2011年 / 52卷 / 04期
关键词
pindone; rodenticide; indandione; LC-MS/MS; analytical method; ANTICOAGULANT RODENTICIDES; MULTIRESIDUE ANALYSIS; MASS-SPECTROMETRY; LIVER; SERUM;
D O I
10.3358/shokueishi.52.237
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
A sensitive and selective analytical method for the determination of pindone in agricultural products by LC-MS/MS was developed. Pindone was extracted with acetone, and an aliquot of the crude extract was re-extracted with hexane. For lipid-rich samples, the crude extract was further cleaned up by acetonitrile-hexane partitioning. The extract was cleaned up on a tandem graphitized carbon-silica gel column. For brown rice, soybean, and tea, PSA column cleanup was added prior to LC-MS/MS determination. Average recoveries of pindone from brown rice, soybean, potato, spinach, cabbage, apple, orange, tomato, cucumber, and tea fortified at 0.001 mg/kg were 81-93%, and the relative standard deviations were 2-7%. The limit of quantitation (S/N >= 10) of the developed method was 0.001 mg/kg for all the tested agricultural products.
引用
收藏
页码:237 / 243
页数:7
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