Performances of Functional and Anatomic Imaging Modalities in Succinate Dehydrogenase A-Related Metastatic Pheochromocytoma and Paraganglioma

被引：12

作者：

Patel, Mayank ^{[1
]}

Jha, Abhishek ^{[1
]}

Ling, Alexander ^{[2
]}

Chen, Clara C. ^{[3
]}

Millo, Corina ^{[4
]}

Kuo, Mickey J. M. ^{[1
,5
]}

Nazari, Matthew A. ^{[1
]}

Talvacchio, Sara ^{[1
]}

Charles, Kailah ^{[1
]}

Miettinen, Markku ^{[6
]}

Del Rivero, Jaydira ^{[7
]}

Chen, Alice P. ^{[8
]}

Nilubol, Naris ^{[9
]}

Lin, Frank I. ^{[10
]}

Civelek, Ali Cahid ^{[11
]}

Taieb, David ^{[12
]}

Carrasquillo, Jorge A. ^{[10
,13
]}

Pacak, Karel ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20814 USA

[2] NIH, Radiol & Imaging Sci, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20814 USA

[3] NIH, Dept Nucl Med, Radiol & Imaging Sci, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20814 USA

[4] NIH, Positron Emiss Tomog Dept, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20814 USA

[5] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA

[6] NCI, Pathol Lab, NIH, Bethesda, MD 20814 USA

[7] NCI, Dev Therapeut Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[8] NCI, Early Clin Trials Dev Program, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA

[9] NCI, Surg Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[10] NCI, Targeted Radionuclide Therapy Sect, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA

[11] Johns Hopkins Med, Div Nucl Med & Mol Imaging, Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

[12] Aix Marseille Univ, Dept Nucl Med, La Timone Univ Hosp, CERIMED, F-13273 Marseille, France

[13] Mem Sloan Kettering Canc Ctr, Dept Radiol, Mol Imaging & Therapy Serv, New York, NY 10065 USA

来源：

CANCERS | 2022年 / 14卷 / 16期

基金：

美国国家卫生研究院;

关键词：

pheochromocytoma; paraganglioma; metastatic; SDHA; PET; CT; MRI; Ga-68-DOTATATE; F-18-FDG; MALIGNANT PHEOCHROMOCYTOMA; BONE METASTASES; SDHA; MUTATIONS; PET/CT;

D O I：

10.3390/cancers14163886

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine cancers which carry the risk of metastatic disease. Pathogenic variants in the succinate dehydrogenase subunit A gene (SDHA) have been shown to cause metastatic disease, occurring in various regions of the body. Imaging is an early and vital step in the diagnosis and clinical care of these patients. The study here identifies which imaging modality among positron emission tomography (PET), computed tomography (CT), and magnetic resonance imaging (MRI) performs better in localizing metastatic PPGL lesions related to SDHA. The study identified that Ga-68-DOTATATE PET/CT performed best at overall lesion detection; however, F-18-FDG PET/CT performed better in certain anatomic regions of the body. A combined approach with Ga-68-DOTATATE and F-18-FDG would optimize care and guide clinicians in selecting the appropriate interventions and therapies. The study identifies the importance of positron emission tomographic (PET) and anatomic imaging modalities and their individual performances in detecting succinate dehydrogenase A (SDHA)-related metastatic pheochromocytoma and paraganglioma (PPGL). The detection rates of PET modalities-Ga-68-DOTATATE, F-18-FDG, and F-18-FDOPA-along with the combination of computed tomography (CT) and magnetic resonance imaging (MRI) are compared in a cohort of 11 patients with metastatic PPGL in the setting of a germline SDHA mutation. The imaging detection performances were evaluated at three levels: overall lesions, anatomic regions, and a patient-by-patient basis. Ga-68-DOTATATE PET demonstrated a lesion-based detection rate of 88.6% [95% confidence interval (CI), 84.3-92.5%], while F-18-FDG, F-18-FDOPA, and CT/MRI showed detection rates of 82.9% (CI, 78.0-87.1%), 39.8% (CI, 30.2-50.2%), and 58.2% (CI, 52.0-64.1%), respectively. The study found that Ga-68-DOTATATE best detects lesions in a subset of patients with SDHA-related metastatic PPGL. However, F-18-FDG did detect more lesions in the liver, mediastinum, and abdomen/pelvis anatomic regions, showing the importance of a combined approach using both PET modalities in evaluating SDHA-related PPGL.

引用

页数：12

共 28 条

[21]

Pacak K., 2000, Endotext

[22] Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors [J].

Strosberg, J. ;

El-Haddad, G. ;

Wolin, E. ;

Hendifar, A. ;

Yao, J. ;

Chasen, B. ;

Mittra, E. ;

Kunz, P. L. ;

Kulke, M. H. ;

Jacene, H. ;

Bushnell, D. ;

O'Dorisio, T. M. ;

Baum, R. P. ;

Kulkarni, H. R. ;

Caplin, M. ;

Lebtahi, R. ;

Hobday, T. ;

Delpassand, E. ;

Van Cutsem, E. ;

Benson, A. ;

Srirajaskanthan, R. ;

Pavel, M. ;

Mora, J. ;

Berlin, J. ;

Grande, E. ;

Reed, N. ;

Seregni, E. ;

Oberg, K. ;

Sierra, M. Lopera ;

Santoro, P. ;

Thevenet, T. ;

Erion, J. L. ;

Ruszniewski, P. ;

Kwekkeboom, D. ;

Krenning, E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (02) :125-135

[23] Molecular imaging and radionuclide therapy of pheochromocytoma and paraganglioma in the era of genomic characterization of disease subgroups [J].

Taieb, David ;

Jha, Abhishek ;

Treglia, Giorgio ;

Pacak, Karel .

[24] European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma [J].

Taieb, David ;

Hicks, Rodney J. ;

Hindie, Elif ;

Guillet, Benjamin A. ;

Avram, Anca ;

Ghedini, Pietro ;

Timmers, Henri J. ;

Scott, Aaron T. ;

Elojeimy, Saeed ;

Rubello, Domenico ;

Virgolini, Irene J. ;

Fanti, Stefano ;

Balogova, Sona ;

Pandit-Taskar, Neeta ;

Pacak, Karel .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (10) :2112-2137

[25] SDHA mutated paragangliomas may be at high risk of metastasis [J].

Tufton, Nicola ;

Ghelani, Rahul ;

Srirangalingam, Umasuthan ;

Kumar, Ajith V. ;

Drake, William M. ;

Iacovazzo, Donato ;

Skordilis, Kassiani ;

Berney, Daniel ;

Al-Mrayat, Ma'en ;

Khoo, Bernard ;

Akker, Scott A. .

[26] Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study [J].

van der Tuin, Karin ;

Mensenkamp, Arjen R. ;

Tops, Carli M. J. ;

Corssmit, Eleonora P. M. ;

Dinjens, Winand N. ;

van de Horst-Schrivers, Anouk N. ;

Jansen, Jeroen C. ;

de Jong, Mirjam M. ;

Kunst, Henricus P. M. ;

Kusters, Benno ;

Leter, Edward M. ;

Morreau, Hans ;

van Nesselrooij, Bernadette M. P. ;

Oldenburg, Rogier A. ;

Spruijt, Liesbeth ;

Hes, Frederik J. ;

Timmers, Henri J. L. M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (02) :438-445

[27] Bone metastases and skeletal-related events from neuroendocrine tumors [J].

Van Loon, Katherine ;

Zhang, Li ;

Keiser, Jennifer ;

Carrasco, Cendy ;

Glass, Katherine ;

Ramirez, Maria-Teresa ;

Bobiak, Sarah ;

Nakakura, Eric K. ;

Venook, Alan P. ;

Shah, Manisha H. ;

Bergsland, Emily K. .

ENDOCRINE CONNECTIONS, 2015, 4 (01)

[28] Eruption of Metastatic Paraganglioma After Successful Therapy with 177Lu/90Y-DOTATOC and 177Lu-DOTATATE [J].

Wolf, Katherine, I ;

AbhishekJha ;

van Berkel, Anouk ;

Wild, Damian ;

Janssen, Ingo ;

Millo, Corina M. ;

Janssen, M. J. R. ;

Gonzales, Melissa K. ;

Timmers, Henri J. K. M. ;

Pacak, Karel .

NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 53 (03) :223-230

← 1 2 3 →