18F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies

被引：1

作者：

Camus, Vincent ^{[1
]}

Edet-Sanson, Agathe ^{[2
]}

Bubenheim, Michael ^{[4
]}

Hitzel, Anne ^{[5
]}

Becker, Stephanie ^{[2
]}

David, Marion ^{[3
]}

Stamatoullas, Aspasia ^{[1
]}

Lenain, Pascal ^{[1
]}

Jardin, Fabrice ^{[1
]}

Contentin, Nathalie ^{[1
]}

Fontoura, Marie Laure ^{[1
]}

Cardinael, Nathalie ^{[1
]}

Vaudaux, Sandrine ^{[1
]}

Dubois, Sydney ^{[1
]}

Tilly, Herve ^{[1
]}

Vera, Pierre ^{[2
]}

Lepretre, Stephane ^{[1
]}

机构：

[1] Ctr Henri Becquerel, Dept Haematol, QuantIF, F-76038 Rouen, France

[2] Ctr Henri Becquerel, Nucl Med, QuantIF, F-76038 Rouen, France

[3] Ctr Henri Becquerel, Dept Biol, F-76038 Rouen, France

[4] Univ Hosp Rouen, Dept Biostat, Rouen, France

[5] Purpan Univ Hosp, Dept Nucl Med, Toulouse, France

来源：

ANTICANCER RESEARCH | 2015年 / 35卷 / 05期

关键词：

F-18-FDG-PET/CT; febrile neutropenia; invasive aspergillosis; haematological malignancies; POSITRON-EMISSION-TOMOGRAPHY; INVASIVE FUNGAL-INFECTIONS; INTRATUMORAL DISTRIBUTION; DIAGNOSIS; CANCER; FLUORODEOXYGLUCOSE; PET/CT; MACROPHAGES; MANAGEMENT;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the present study was to assess the prevalence of hyper-metabolic infection sites revealed by fluorine-18 (F-18) fluorodeoxyglucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) in patients with febrile neutropenia (FN). Forty-eight consecutive patients with haematological malignancies and persistent FN (temperature >= 38 degrees C and neutrophil count <500 cells/mu l for more than two days) as a consequence of intensive chemotherapy were prospectively included. Pathological FDG uptakes identified 31 foci of infections located in the lungs (n=15, 48.4 %), colon (n=4, 12.9%), pancreas (n=2, 6.5%), skin (n=3, 9.7%), ear-nose-throat area (n=5, 16.1%), central venous catheter tract (n=1, 3.2%) and gallbladder (n=1, 3.2%). These pathological FDG uptakes were observed in half of the 48 patients (n=24). Among the 38 patients with a clinical diagnosis of infection, 23 showed a pathological FDG uptake, resulting in a FDG-PET/CT sensitivity of 61% (95% CI, 43-76%). Our study confirmed the ability of FDG-PET/CT to diagnose infections in patients with persistent FN.

引用

页码：2999 / 3005

页数：7

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