18F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies

被引：1

作者：

Camus, Vincent ^{[1
]}

Edet-Sanson, Agathe ^{[2
]}

Bubenheim, Michael ^{[4
]}

Hitzel, Anne ^{[5
]}

Becker, Stephanie ^{[2
]}

David, Marion ^{[3
]}

Stamatoullas, Aspasia ^{[1
]}

Lenain, Pascal ^{[1
]}

Jardin, Fabrice ^{[1
]}

Contentin, Nathalie ^{[1
]}

Fontoura, Marie Laure ^{[1
]}

Cardinael, Nathalie ^{[1
]}

Vaudaux, Sandrine ^{[1
]}

Dubois, Sydney ^{[1
]}

Tilly, Herve ^{[1
]}

Vera, Pierre ^{[2
]}

Lepretre, Stephane ^{[1
]}

机构：

[1] Ctr Henri Becquerel, Dept Haematol, QuantIF, F-76038 Rouen, France

[2] Ctr Henri Becquerel, Nucl Med, QuantIF, F-76038 Rouen, France

[3] Ctr Henri Becquerel, Dept Biol, F-76038 Rouen, France

[4] Univ Hosp Rouen, Dept Biostat, Rouen, France

[5] Purpan Univ Hosp, Dept Nucl Med, Toulouse, France

来源：

ANTICANCER RESEARCH | 2015年 / 35卷 / 05期

关键词：

F-18-FDG-PET/CT; febrile neutropenia; invasive aspergillosis; haematological malignancies; POSITRON-EMISSION-TOMOGRAPHY; INVASIVE FUNGAL-INFECTIONS; INTRATUMORAL DISTRIBUTION; DIAGNOSIS; CANCER; FLUORODEOXYGLUCOSE; PET/CT; MACROPHAGES; MANAGEMENT;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the present study was to assess the prevalence of hyper-metabolic infection sites revealed by fluorine-18 (F-18) fluorodeoxyglucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) in patients with febrile neutropenia (FN). Forty-eight consecutive patients with haematological malignancies and persistent FN (temperature >= 38 degrees C and neutrophil count <500 cells/mu l for more than two days) as a consequence of intensive chemotherapy were prospectively included. Pathological FDG uptakes identified 31 foci of infections located in the lungs (n=15, 48.4 %), colon (n=4, 12.9%), pancreas (n=2, 6.5%), skin (n=3, 9.7%), ear-nose-throat area (n=5, 16.1%), central venous catheter tract (n=1, 3.2%) and gallbladder (n=1, 3.2%). These pathological FDG uptakes were observed in half of the 48 patients (n=24). Among the 38 patients with a clinical diagnosis of infection, 23 showed a pathological FDG uptake, resulting in a FDG-PET/CT sensitivity of 61% (95% CI, 43-76%). Our study confirmed the ability of FDG-PET/CT to diagnose infections in patients with persistent FN.

引用

页码：2999 / 3005

页数：7

共 25 条

[1] Risks, diagnosis and outcomes of invasive fungal infections in haematopoietic stem cell transplant recipients [J].

Barnes, Penelope D. ;

Marr, Kieren A. .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 139 (04) :519-531

[2] FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 [J].

Boellaard, Ronald ;

O'Doherty, Mike J. ;

Weber, Wolfgang A. ;

Mottaghy, Felix M. ;

Lonsdale, Markus N. ;

Stroobants, Sigrid G. ;

Oyen, Wim J. G. ;

Kotzerke, Joerg ;

Hoekstra, Otto S. ;

Pruim, Jan ;

Marsden, Paul K. ;

Tatsch, Klaus ;

Hoekstra, Corneline J. ;

Visser, Eric P. ;

Arends, Bertjan ;

Verzijlbergen, Fred J. ;

Zijlstra, Josee M. ;

Comans, Emile F. I. ;

Lammertsma, Adriaan A. ;

Paans, Anne M. ;

Willemsen, Antoon T. ;

Beyer, Thomas ;

Bockisch, Andreas ;

Schaefer-Prokop, Cornelia ;

Delbeke, Dominique ;

Baum, Richard P. ;

Chiti, Arturo ;

Krause, Bernd J. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2010, 37 (01) :181-200

[3]

BROWN RS, 1995, J NUCL MED, V36, P1854

[4] Management of febrile neutropenia: ESMO Clinical Practice Guidelines [J].

de Naurois, J. ;

Novitzky-Basso, I. ;

Gill, M. J. ;

Marti, F. Marti ;

Cullen, M. H. ;

Roila, F. .

ANNALS OF ONCOLOGY, 2010, 21 :v252-v256

[5] Contribution of new diagnostic approaches to antifungal treatment plans in high-risk haematology patients [J].

Einsele, H. ;

Loeffler, J. .

CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 :37-45

[6] NOTE ON AN EXACT TREATMENT OF CONTINGENCY, GOODNESS OF FIT AND OTHER PROBLEMS OF SIGNIFICANCE [J].

FREEMAN, GH ;

HALTON, JH .

BIOMETRIKA, 1951, 38 (1-2) :141-149

[7] The role of 18F-FDG PET/CT for the diagnosis of infections in patients with hematological malignancies and persistent febrile neutropenia [J].

Gafter-Gvili, Anat ;

Paul, Mical ;

Bernstine, Hanna ;

Vidal, Liat ;

Ram, Ron ;

Raanani, Pia ;

Yeshurun, Moshe ;

Tadmor, Boaz ;

Leibovici, Leonard ;

Shpilberg, Ofer ;

Groshar, David .

LEUKEMIA RESEARCH, 2013, 37 (09) :1057-1062

[8] Augmentations of glucose uptake and glucose transporter-1 in macrophages following thermal injury and sepsis in mice [J].

Gamelli, RL ;

Liu, H ;

He, LK ;

Hofmann, CA .

JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 59 (05) :639-647

[9] Use of FDG PET/CT for investigation of febrile neutropenia: evaluation in high-risk cancer patients [J].

Guy, Stephen D. ;

Tramontana, Adrian R. ;

Worth, Leon J. ;

Lau, Eddie ;

Hicks, Rodney J. ;

Seymour, John F. ;

Thursky, Karin A. ;

Slavin, Monica A. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (08) :1348-1355

[10] Positron emission scanning with 18-FDG in the diagnosis of deep fungal infections [J].

Ho, AYL ;

Pagliuca, A ;

Maisey, MN ;

Mufti, GJ .

BRITISH JOURNAL OF HAEMATOLOGY, 1998, 101 (02) :392-393

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