Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat

被引：13

作者：

Bi, Wei ^{[1
]}

Bi, Yue ^{[4
]}

Xue, Ping ^{[1
]}

Zhang, Yanrong ^{[1
]}

Gao, Xiang ^{[1
]}

Wang, Zhibo ^{[1
]}

Li, Meng ^{[1
]}

Baudy-Floc'h, Michele ^{[5
]}

Ngerebara, Nathaniel ^{[2
]}

Li, Xiaoxu ^{[6
]}

Gibson, K. Michael ^{[3
]}

Bi, Lanrong ^{[2
]}

机构：

[1] HeBei Med Univ, Hosp 2, Dept Surg, Shijiazhuang 050000, Peoples R China

[2] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[3] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA

[4] HeBei Med Univ, Sch Basic Med Sci, Shijiazhuang 050000, Peoples R China

[5] Univ Rennes 1, ICMV, CNRS, UMR 6226, F-35042 Rennes, France

[6] Columbia Univ, Columbia Univ Coll Phys & Surg, New York, NY 10027 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 06期

关键词：

Ischemia/reperfusion injury; Anti-inflammatory activity; Analgesic activity; beta-carboline-tripeptide conjugate; ISCHEMIA-REPERFUSION INJURY; ANTIINFLAMMATORY ACTIVITIES; PC12; CELLS; CHEMOPREVENTION AGENTS; BRAIN MITOCHONDRIA; OXIDATIVE STRESS; ANTIOXIDANT; 2,5-DISUBSTITUTED-DIOXACYCLOALKANES; PATHOPHYSIOLOGY; HARMALINE;

D O I：

10.1016/j.ejmech.2011.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized a series of new beta-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that beta-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat. Published by Elsevier Masson SAS.

引用

页码：2441 / 2452

页数：12

共 29 条

[1] Acute mesenteric ischemia [J].

Berland T. ;

Oldenburg W.A. .

Current Gastroenterology Reports, 2008, 10 (3) :341-346

[2]

Beutler E., 1975, Red Cell Metabolism. A manual of biochemical methods, V2nd

[3] Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes [J].

Bi, Lanrong ;

Zhao, Ming ;

Gu, Keli ;

Wang, Chao ;

Ju, Jingfang ;

Peng, Shiqi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (04) :1764-1774

[4] Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes [J].

Bi, LR ;

Zhang, Y ;

Zhao, M ;

Wang, C ;

Chan, P ;

Tok, JBH ;

Peng, SQ .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (19) :5640-5646

[5]

Buege J A, 1978, Methods Enzymol, V52, P302

[6] Pathophysiology clinical manifestations, and prevention of ischemia-reperfusion injury [J].

Collard, CD ;

Gelman, S .

ANESTHESIOLOGY, 2001, 94 (06) :1133-1138

[7]

Rodríguez AD, 2009, REV ESP CARDIOL, V62, P952, DOI [10.1016/S0300-8932(09)72087-1, 10.1016/S0300-8932(09)73092-1]

[8]

Garcia-Rivas Gerardo J, 2009, Methodist Debakey Cardiovasc J, V5, P2

[9]

GU K, 2007, BIOORGAN MED CHEM, P6273

[10] Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes [J].

Gu, Keli ;

Bi, Lanrong ;

Zhao, Ming ;

Wang, Chao ;

Ju, Jingfang ;

Peng, Shiqi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (14) :4775-4799

← 1 2 3 →