Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat

被引：13

作者：

Bi, Wei ^{[1
]}

Bi, Yue ^{[4
]}

Xue, Ping ^{[1
]}

Zhang, Yanrong ^{[1
]}

Gao, Xiang ^{[1
]}

Wang, Zhibo ^{[1
]}

Li, Meng ^{[1
]}

Baudy-Floc'h, Michele ^{[5
]}

Ngerebara, Nathaniel ^{[2
]}

Li, Xiaoxu ^{[6
]}

Gibson, K. Michael ^{[3
]}

Bi, Lanrong ^{[2
]}

机构：

[1] HeBei Med Univ, Hosp 2, Dept Surg, Shijiazhuang 050000, Peoples R China

[2] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[3] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA

[4] HeBei Med Univ, Sch Basic Med Sci, Shijiazhuang 050000, Peoples R China

[5] Univ Rennes 1, ICMV, CNRS, UMR 6226, F-35042 Rennes, France

[6] Columbia Univ, Columbia Univ Coll Phys & Surg, New York, NY 10027 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 06期

关键词：

Ischemia/reperfusion injury; Anti-inflammatory activity; Analgesic activity; beta-carboline-tripeptide conjugate; ISCHEMIA-REPERFUSION INJURY; ANTIINFLAMMATORY ACTIVITIES; PC12; CELLS; CHEMOPREVENTION AGENTS; BRAIN MITOCHONDRIA; OXIDATIVE STRESS; ANTIOXIDANT; 2,5-DISUBSTITUTED-DIOXACYCLOALKANES; PATHOPHYSIOLOGY; HARMALINE;

D O I：

10.1016/j.ejmech.2011.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized a series of new beta-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that beta-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat. Published by Elsevier Masson SAS.

引用

页码：2441 / 2452

页数：12

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