A comprehensive review of the roles of E2F1 in colon cancer

被引：6
作者：
Fang, Zejun [1 ,2 ]
Lin, Min [1 ]
Li, Chunxiao [3 ]
Liu, Hong [4 ,5 ]
Gong, Chaoju [6 ]
机构：
[1] Zhejiang Univ, Cent Lab, Sanmen Peoples Hosp Zhejiang, Sanmenwan Branch,Affiliated Hosp 1,Coll Med, Sanmen 317100, Peoples R China
[2] Zhejiang Univ, Dept Gastroenterol, Sanmen Peoples Hosp Zhejiang, Sanmenwan Branch,Affiliated Hosp 1,Coll Med, Sanmen 317100, Peoples R China
[3] Ningbo First Hosp, Dept Gastroenterol, Ningbo 315010, Zhejiang, Peoples R China
[4] Zhejiang Normal Univ Peoples Hosp Joint Ctr Biome, Jinhua 321004, Zhejiang, Peoples R China
[5] Temple Univ, Dept Neurosci, Ctr Neurovirol, Lewis Katz Sch Med, Philadelphia, PA 19140 USA
[6] Xuzhou Med Univ, Municipal Affiliated Hosp, Cent Lab, Xuzhou 221002, Jiangsu, Peoples R China
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2020年 / 10卷 / 03期
基金：
中国国家自然科学基金;
关键词：
E2F1; colon cancer; proliferation; chemoresistance; apoptosis; CELL-CYCLE ARREST; APOPTOSIS PROTEIN-1 CIAP1; COLORECTAL-CANCER; TRANSCRIPTION FACTOR; THYMIDYLATE SYNTHASE; ALDOSE REDUCTASE; GENE-EXPRESSION; TUMOR-SUPPRESSOR; DOWN-REGULATION; GROWTH;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 recognition site. The dissociation of E2F1 from retinoblastoma (Rb) protein recovers its transcriptional activity, which drives the cell cycle from the G1 to S phase. E2F1 has been shown to be involved in cellular proliferation, differentiation, and apoptosis in colon cancer. It was recently found that E2F1 also participates in the metastasis and chemoresistance of colon cancer. There are abundant experimental data regarding the actions of E2F1, which can be grouped as either pro-tumorigenic or pro-apoptotic. Despite a growing interest and plentiful data, there is currently no review that focuses on the role of E2F1 in colon cancer. Research on E2F1 and colon cancer has been scattered over various genes and microRNAs (miRNAs) that affect E2F1 expression. Here, we provide the first review that aims to consider and dissect all of the elucidated complex behaviors of E2F1 in colon cancer. This review also provides an analysis and conclusion regarding the current understanding of E2F1 in colon cancer in order to facilitate the direction of future research.
引用
收藏
页码：757 / 768
页数：12
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