Gene expression profiles in the brain predict behavior in individual honey bees

被引：452
作者：
Whitfield, CW
Cziko, AM
Robinson, GE [1 ]
机构：
[1] Univ Illinois, Dept Entomol, 320 Morrill Hall,505 S Goodwin Ave, Urbana, IL 61801 USA
[2] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA
来源：
SCIENCE | 2003年 / 302卷 / 5643期
关键词：
D O I：
10.1126/science.1086807
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We show that the age-related transition by adult honey bees from hive work to foraging is associated with changes in messenger RNA abundance in the brain for 39% of similar to5500 genes tested. This result, discovered using a highly replicated experimental design involving 72 microarrays, demonstrates more extensive genomic plasticity in the adult brain than has yet been shown. Experimental manipulations that uncouple behavior and age revealed that messenger RNA changes were primarily associated with behavior. Individual brain messenger RNA profiles correctly predicted the behavior of 57 out of 60 bees, indicating a robust association between brain gene expression in the individual and naturally occurring behavioral plasticity.
引用
收藏
页码：296 / 299
页数：4
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