Effects of ovarian steroids on immunoglobulin-secreting cell function in healthy women

被引：15

作者：

Lü, FX

Ma, ZM

Moser, S

Evans, TG

Miller, CJ ^{[1
]}

机构：

[1] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

[2] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA

[4] Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA

[5] Univ Calif Davis, Dept Internal Med, Sch Med, Davis, CA 95616 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2003年 / 10卷 / 05期

关键词：

D O I：

10.1128/CDLI.10.5.944-949.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine the effect of the ovarian hormone cycle on immunity, immunoglobulin-secreting cell (ISC) frequency and lymphocyte subsets were examined in the blood of healthy women. We found that immunoglobulin A (IgA)-secreting cells (IgA-ISC) were fourfold more frequent than IgG-ISC in peripheral blood mononuclear cells (PBMC). Further, the ISC frequency in PBMC was highest (P < 0.05) during the periovulatory stage of the menstrual cycle. Thus, endogenous ovarian steroids regulate the ISC frequency and this may explain why women are more resistant to viral infections and tend to have more immune-mediated diseases than men do.

引用

页码：944 / 949

页数：6

共 38 条

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