Ultra-pH-Sensitive Small Molecule Probe Showing a Ratiometric Fluorescence Color Change

被引：12

作者：

Cui, Junjie ^{[1
]}

Kim, Gayoung ^{[2
]}

Kim, Sehoon ^{[2
]}

Kwon, Ji Eon ^{[1
]}

Park, Soo Young ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Mat Sci & Engn, Ctr Supramol Optoelect Mat, Res Inst Adv Mat, 1 Gwanak Ro, Seoul 08826, South Korea

[2] Korea Inst Sci & Technol, Ctr Theragnosis, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea

来源：

CHEMPHOTOCHEM | 2020年 / 4卷 / 06期

关键词：

amphiphiles; bioimaging; fluorescence switching; pH responsiveness; self-assembly; supramolecular chemistry; INTRACELLULAR PH; RANGE; DESIGN; NANOFIBERS; VALUES; SENSOR; WATER;

D O I：

10.1002/cptc.202000023

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We synthesized an amphiphilic small molecule 1 by attaching oligo(ethylene glycol) (OEG) and N,N-diethylamine (DEA) units to a fluorescent dicyanodistyrylbenzene (DCS) core. The molecule is fully soluble in aqueous solution at low pH (pH<4.3) by protonation of the DEA groups; but, above pH 4.3, it self-assembles to form nanoparticles due to increased hydrophobicity upon deprotonation, leading to a ratiometric fluorescence color change from green emission in the monomeric form (lambda(em,max)=538 nm) to red emission in the aggregated form (lambda(em,max)=646 nm). It should be noted that the ratio of emission intensities at 538 nm and 646 nm (R=I-538/I-646) changes drastically about 42-fold within a very narrow pH range of 4.3-4.6.

引用

页码：393 / 397

页数：5

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