Recent advances in asymmetric C-C and C-heteroatom bond forming reactions using polymer-bound catalysts

The synthesis of enantiomerically pure compounds is one of the major challenges in organic synthesis. In this review, we present the state of the art in asymmetric catalysis using immobilized chiral ligands and complexes for asymmetric C-C and C-heteroatom bond forming reactions. Chiral catalysts based on dendrimers and soluble polymeric supports are considered. In particular, addition reactions to carbon-carbon double bonds, asymmetric 1,2-addition reactions using, e.g., dialkylzinc reagents, metal-catalyzed substitution reactions and cycloaddition reactions are covered. Specific emphasis is placed on enantioselective epoxidation and aldol reactions. A further aspect is the (hetero) Diels-Alder reaction catalyzed by immobilized ligands.