β-D-glycosylamidines:: Potent, selective, and easily accessible β-glycosidase inhibitors

被引：41

作者：

Guo, WF

Hiratake, J ^{[1
]}

Ogawa, K

Yamamoto, M

Ma, SJ

Sakata, K

机构：

[1] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan

[2] Nihon Shokuhin Kako Co Ltd, Res Inst, Shizuoka 4178530, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00706-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

beta -D-Glycosylamidines, in which a glycon is connected via an N-glycoside linkage with a substituted amidine (aglycon), were synthesized in two steps from the corresponding sugars and served as stable and potent beta -glycdsidase inhibitors with high selectivity according to the glycon- and alpha, beta -specificities of the enzymes. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：467 / 470

页数：4

共 34 条

[1] Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application [J].