Do NIA-AA criteria distinguish Alzheimer's disease from frontotemporal dementia?

被引：23
作者：
Harris, Jennifer M. [1 ,2 ]
Thompson, Jennifer C. [1 ]
Gall, Claire [1 ]
Richardson, Anna M. T. [1 ,2 ]
Neary, David [1 ,2 ]
du Plessis, Daniel [1 ]
Pal, Piyali [1 ]
Mann, David M. A. [1 ,2 ]
Snowden, Julie S. [1 ,2 ]
Jones, Matthew [1 ,2 ]
机构：
[1] Salford Royal NHS Fdn Trust, Greater Manchester Neurosci Ctr, Manchester Acad Hlth Sci Ctr, Cerebral Funct Unit, Salford, Lancs, England
[2] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
来源：
ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 02期
关键词：
Alzheimer's disease; Dementia; Diagnosis; Criteria; Pathology; Neuropathology; CLINICAL DIAGNOSTIC-CRITERIA; NINCDS-ADRDA CRITERIA; NATIONAL-INSTITUTE; ASSOCIATION WORKGROUPS; BEHAVIORAL VARIANT; LEWY BODIES; TASK-FORCE; GUIDELINES; RECOMMENDATIONS; VALIDITY;
D O I：
10.1016/j.jalz.2014.04.516
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies. Objective: The aim was to assess the National Institute on Aging and Alzheimer's Association (NIA-AA) criteria for Alzheimer's disease (AD) dementia in AD and frontotemporal lobar degeneration (FTLD). Methods: Two hundred twelve consecutive patients with pathologically confirmed AD or FTLD who were clinically assessed in a specialist cognitive unit were identified. Fifty-five patients were excluded predominantly because of insufficient clinical information. Anonymized clinical data were rated against the NIA-AA criteria by raters who were blinded to clinical and pathologic diagnosis. Results: The NIA-AA AD dementia criteria had a sensitivity of 65.6% for probable and 79.5% for possible AD and a specificity of 95.2% and 94.0% for probable and possible, respectively. Conclusion: In patients with FTLD and predominantly early-onset AD, the NIA-AA AD dementia criteria have high specificity but lower sensitivity. The high specificity is due to the broad exclusion criteria. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：207 / 215
页数：9
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