Enantioselective total synthesis of the polycyclic guanidine-containing marine alkaloid (-)-batzelladine D

被引：57

作者：

Evans, P. Andrew ^{[1
]}

Qin, Jun

Robinson, John E.

Bazin, Berangere

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 39期

关键词：

alkaloids; asymmetric synthesis; guanidines; natural products; total synthesis;

D O I：

10.1002/anie.200700840

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Addressing the marine core: The enantioselective total synthesis of the polycyclic guanidine-containing marine alkaloid (-)-batzelladine D has been accomplished using a convergent 14-step reaction sequence (longest linear sequence) in 10% overall yield. The ability to accomplish the selective homolytic cleavage of an alkyl iodide in the presence of an azide circumvents the necessity for nitrogen-protecting groups. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7417 / 7419

页数：3

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