Alzheimer's Disease and Rheumatoid Arthritis: A Mendelian Randomization Study

被引：21

作者：

Cai, Qixuan ^{[1
]}

Xin, Zhuoyuan ^{[1
]}

Zuo, Lin ^{[2
]}

Li, Fan ^{[1
]}

Liu, Bin ^{[3
]}

机构：

[1] Jilin Univ, Coll Basic Med Sci, Key Lab Zoonosis Res, Minist Educ, Changchun, Jilin, Peoples R China

[2] Jilin Univ, Dept Anesthesiol, China Japan Union Hosp, Changchun, Jilin, Peoples R China

[3] Jilin Univ, Hosp 1, Ctr Cardiovasc Dis, Changchun, Jilin, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; rheumatoid arthritis; genome-wide association study; Mendelian randomization; autoimmune disease; GENOME-WIDE ASSOCIATION; POLYMORPHISM CONTRIBUTES; GENE-EXPRESSION; SAMPLES CONFIRMS; COMMON VARIANTS; SUSCEPTIBILITY; RISK; CD33; CD2AP; EPHA1;

D O I：

10.3389/fnins.2018.00627

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is the most common neurodegenerative disease. In recent years, multiple pathway analyses of AD genome-wide association studies (GWAS) have been conducted, and provided strong support for immune pathways in AD. Rheumatoid arthritis (RA) is a chronic autoimmune disease. It is reported that antirheumatic drugs had protective effect on dementia in RA patients. However, observational studies have reported a controversial inverse relationship between AD and RA. In addition, Mendelian randomization studies have also been performed to evaluate the association of RA with AD. However, these studies reported inconsistent association of RA with AD. Until now, it is still unclear that AD is a causally associated with RA. Here, we performed a Mendelian randomization study to investigate the causal association of AD with RA. We analyzed the large-scale AD GWAS dataset (74,046 individuals) and RA GWAS dataset (58,284 individuals) from the European descent. However, we did not identify any significant association of AD with RA using inverse-variance weighted meta-analysis (IVW), weighted median regression and MR-Egger regression.

引用

页数：5

共 45 条

[31] PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population [J].

Liu, Guiyou ;

Zhang, Shuyan ;

Cai, Zhiyou ;

Ma, Guoda ;

Zhang, Liangcai ;

Jiang, Yongshuai ;

Feng, Rennan ;

Liao, Mingzhi ;

Chen, Zugen ;

Zhao, Bin ;

Li, Keshen .

NEUROMOLECULAR MEDICINE, 2013, 15 (02) :384-388

[32] Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup [J].

Liu, Guiyou ;

Zhang, Liangcai ;

Feng, Rennan ;

Liao, Mingzhi ;

Jiang, Yongshuai ;

Chen, Zugen ;

Zhao, Bin ;

Li, Keshen .

NEUROBIOLOGY OF AGING, 2013, 34 (04) :1310.e9-1310.e10

[33] Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies [J].

Liu, Guiyou ;

Jiang, Yongshuai ;

Wang, Ping ;

Feng, Rennan ;

Jiang, Nan ;

Chen, Xiaoyun ;

Song, Hui ;

Chen, Zugen .

JOURNAL OF NEUROCHEMISTRY, 2012, 120 (01) :190-198

[34] Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease [J].

Naj, Adam C. ;

Jun, Gyungah ;

Beecham, Gary W. ;

Wang, Li-San ;

Vardarajan, Badri Narayan ;

Buros, Jacqueline ;

Gallins, Paul J. ;

Buxbaum, Joseph D. ;

Jarvik, Gail P. ;

Crane, Paul K. ;

Larson, Eric B. ;

Bird, Thomas D. ;

Boeve, Bradley F. ;

Graff-Radford, Neill R. ;

De Jager, Philip L. ;

Evans, Denis ;

Schneider, Julie A. ;

Carrasquillo, Minerva M. ;

Ertekin-Taner, Nilufer ;

Younkin, Steven G. ;

Cruchaga, Carlos ;

Kauwe, John S. K. ;

Nowotny, Petra ;

Kramer, Patricia ;

Hardy, John ;

Huentelman, Matthew J. ;

Myers, Amanda J. ;

Barmada, Michael M. ;

Demirci, F. Yesim ;

Baldwin, Clinton T. ;

Green, Robert C. ;

Rogaeva, Ekaterina ;

St George-Hyslop, Peter ;

Arnold, Steven E. ;

Barber, Robert ;

Beach, Thomas ;

Bigio, Eileen H. ;

Bowen, James D. ;

Boxer, Adam ;

Burke, James R. ;

Cairns, Nigel J. ;

Carlson, Chris S. ;

Carney, Regina M. ;

Carroll, Steven L. ;

Chui, Helena C. ;

Clark, David G. ;

Corneveaux, Jason ;

Cotman, Carl W. ;

Cummings, Jeffrey L. ;

DeCarli, Charles .

NATURE GENETICS, 2011, 43 (05) :436-+

[35] Genetics of rheumatoid arthritis contributes to biology and drug discovery [J].

Okada, Yukinori ;

Wu, Di ;

Trynka, Gosia ;

Raj, Towfique ;

Terao, Chikashi ;

Ikari, Katsunori ;

Kochi, Yuta ;

Ohmura, Koichiro ;

Suzuki, Akari ;

Yoshida, Shinji ;

Graham, Robert R. ;

Manoharan, Arun ;

Ortmann, Ward ;

Bhangale, Tushar ;

Denny, Joshua C. ;

Carroll, Robert J. ;

Eyler, Anne E. ;

Greenberg, Jeffrey D. ;

Kremer, Joel M. ;

Pappas, Dimitrios A. ;

Jiang, Lei ;

Yin, Jian ;

Ye, Lingying ;

Su, Ding-Feng ;

Yang, Jian ;

Xie, Gang ;

Keystone, Ed ;

Westra, Harm-Jan ;

Esko, Tonu ;

Metspalu, Andres ;

Zhou, Xuezhong ;

Gupta, Namrata ;

Mirel, Daniel ;

Stahl, Eli A. ;

Diogo, Dorothee ;

Cui, Jing ;

Liao, Katherine ;

Guo, Michael H. ;

Myouzen, Keiko ;

Kawaguchi, Takahisa ;

Coenen, Marieke J. H. ;

van Riel, Piet L. C. M. ;

van de laar, Mart A. F. J. ;

Guchelaar, Henk-Jan ;

Huizinga, Tom W. J. ;

Dieude, Philippe ;

Mariette, Xavier ;

Bridges, S. Louis, Jr. ;

Zhernakova, Alexandra ;

Toes, Rene E. M. .

NATURE, 2014, 506 (7488) :376-+

[36] Rheumatoid arthritis and risk for Alzheimer's disease: a systematic review and meta-analysis and a Mendelian Randomization study [J].

Policicchio, Stefania ;

Ahmad, Aminah Noor ;

Powell, John Francis ;

Proitsi, Petroula .

SCIENTIFIC REPORTS, 2017, 7

[37] An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease [J].

Shen, Ning ;

Chen, Bin ;

Jiang, Yongshuai ;

Feng, Rennan ;

Liao, Mingzhi ;

Zhang, Liangcai ;

Li, Fujun ;

Ma, Guoda ;

Chen, Zugen ;

Zhao, Bin ;

Li, Keshen ;

Liu, Guiyou .

MOLECULAR NEUROBIOLOGY, 2015, 51 (03) :1017-1023

[38] Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease [J].

Sims, Rebecca ;

van der Lee, Sven J. ;

Naj, Adam C. ;

Bellenguez, Celine ;

Badarinarayan, Nandini ;

Jakobsdottir, Johanna ;

Kunkle, Brian W. ;

Boland, Anne ;

Raybould, Rachel ;

Bis, Joshua C. ;

Martin, Eden R. ;

Grenier-Boley, Benjamin ;

Heilmann-Heimbach, Stefanie ;

Chouraki, Vincent ;

Kuzma, Amanda B. ;

Sleegers, Kristel ;

Vronskaya, Maria ;

Ruiz, Agustin ;

Graham, Robert R. ;

Olaso, Robert ;

Hoffmann, Per ;

Grove, Megan L. ;

Vardarajan, Badri N. ;

Hiltunen, Mikko ;

Noethen, Markus M. ;

White, Charles C. ;

Hamilton-Nelson, Kara L. ;

Epelbaum, Jacques ;

Maier, Wolfgang ;

Choi, Seung-Hoan ;

Beecham, Gary W. ;

Dulary, Cecile ;

Herms, Stefan ;

Smith, Albert V. ;

Funk, Cory C. ;

Derbois, Celine ;

Forstner, Andreas J. ;

Ahmad, Shahzad ;

Li, Hongdong ;

Bacq, Delphine ;

Harold, Denise ;

Satizabal, Claudia L. ;

Valladares, Otto ;

Squassina, Alessio ;

Thomas, Rhodri ;

Brody, Jennifer A. ;

Qu, Liming ;

Sanchez-Juan, Pascual ;

Morgan, Taniesha ;

Wolters, Frank J. .

NATURE GENETICS, 2017, 49 (09) :1373-+

[39] Rheumatoid arthritis and the risk of dementia: A systematic review and meta-analysis [J].

Ungprasert, Patompong ;

Wijarnpreecha, Karn ;

Thongprayoon, Charat .

NEUROLOGY INDIA, 2016, 64 (01) :56-61

[40] HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants [J].

Ward, Lucas D. ;

Kellis, Manolis .

NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) :D930-D934

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