Alteration of Biomechanical Properties of Skin During the Course of Healing of Partial-thickness Wounds

The incidence of partial-thickness wounds is high and, until recently, little was known about the alteration of the biomechanical properties of the skin in these wounds during the course of healing. The aim of this study was to demonstrate the biomechanical changes in skin elasticity. Materials and Methods. Fourteen standardized skin defects were created on the back of fourteen adult male Lewis rats (Charles River Laboratories International, Inc, Wilmington, MA) using a skin dermatome. Biomechanical properties of the skin were determined every 10 days over a period of 3 months using a skin elasticity measurement device (Cutometer MPA 580, Courage and K-hazaka, Cologne, Germany). Calculated elasticity (UE), firmness of skin (R0), and overall elasticity (R8) were assessed. In addition, histological evaluation was performed in regard to quality of skin. Results. After an initial decrease of UE, R0, and R8 until 30 days after surgery, the values of R0 and R8 increased between day 50 and day 60. Starting on day 60, a further decrease of values was indicated. Conclusion. The alteration of biomechanical properties of skin is a function of tissue structure. The presented results demonstrate the complex changes of skin biomechanical properties in the course of healing of partial-thickness wounds. This study could serve as a model to compare the effectiveness of different Wound dressings in regard to skin elasticity.