Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatography for purification

被引：46
作者：
Boger, DL
Goldberg, J
Andersson, CM
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Lund Univ, S-22100 Lund, Sweden
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 07期
关键词：
D O I：
10.1021/jo982234v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and effective approach to the solution phase synthesis of biaryl libraries from iodoarenes is described enlisting 10% Pd-C as an inexpensive and readily available supported catalyst. Isolation and purification of small library mixtures, individual library members, and intermediates in the multistep sequence by a combination of liquid-liquid and liquid-solid extractions and size exclusion chromatography are detailed.
引用
收藏
页码：2422 / 2427
页数：6
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