Efficient one-pot preparation of novel fused chromeno[2,3-d]pyrimidine and pyrano[2,3-d]pyrimidine derivatives

被引：80

作者：

Aly, Hala M. ^{[1
]}

Kamal, Mona M. ^{[2
]}

机构：

[1] Al Azhar Univ, Fac Sci Girls, Dept Chem, Nasr City, Cairo, Egypt

[2] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Nasr City, Cairo, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 47卷

关键词：

Pyrimidine; Antibacterial activity; Antifungal activity; ANTITUMOR-ACTIVITY; 4-HYDROXYCOUMARIN; THIENOPYRIMIDINE; ACID;

D O I：

10.1016/j.ejmech.2011.09.040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some novel chromeno[2,3-d]pyrimidinone, pyrano[2,3-d]pyrimidine, dihydropyrimidine, pyridopyranopyrimidine and pyrimidopyranopyrimidine have been synthesized. The structures of target compounds were confirmed by elemental analyses and spectral data. The antimicrobial activity of all the target synthesized compounds were tested against various microorganismst such as Pseudomonas aeruginosa; Staphylococcus aureus (Bacteria), Aspergillus flavus (Fungus) and Candida albicans (Yeast fungus) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：18 / 23

页数：6

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