Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China

被引：17

作者：

Fu, Yingmei ^{[1
,2
]}

Guo, Lishuang ^{[1
]}

Xu, Yan ^{[1
]}

Zhang, Wenli ^{[1
]}

Gu, Jiaao ^{[1
]}

Xu, Jianfeng ^{[1
]}

Chen, Xiaobei ^{[1
]}

Zhao, Yuehui ^{[1
]}

Ma, Jiayu ^{[1
]}

Liu, Xinghan ^{[2
]}

Zhang, Fengmin ^{[1
,2
]}

机构：

[1] Harbin Med Coll, Dept Med Microbiol, Pathogen Biol Key Lab Heilongjiang Prov, Harbin 150086, Peoples R China

[2] Bio Pharmaceut Key Lab Heilongjiang Prov, Harbin 150086, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 08期

关键词：

D O I：

10.1128/AAC.00151-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83 -> Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).

引用

页码：2980 / 2983

页数：4

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