The Ph1 Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat

被引：68

作者：

Greer, Emma ^{[1
]}

Martin, Azahara C. ^{[1
]}

Pendle, Ali ^{[1
]}

Colas, Isabelle ^{[1
]}

Jones, Alexandra M. E. ^{[2
]}

Moore, Graham ^{[1
]}

Shaw, Peter ^{[1
]}

机构：

[1] John Innes Ctr, Norwich NR4 7UH, Norfolk, England

[2] Sainsbury Lab, Norwich NR4 7UH, Norfolk, England

来源：

PLANT CELL | 2012年 / 24卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

HISTONE H1; CHROMATIN CONDENSATION; STATISTICAL-MODEL; OKADAIC ACID; CELL-CYCLE; PHOSPHORYLATION; REPLICATION; CHROMOSOMES; RECOMBINATION; DISSECTION;

D O I：

10.1105/tpc.111.094771

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.

引用

页码：152 / 162

页数：11

共 11 条

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[2] Wild and Cultivated Homoeologous Barley Chromosomes Can Associate and Recombine in Wheat in the Absence of the Ph1 Locus
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[3] The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis
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[4] Dosage Effect of the Ph1 Locus on Homologous Crossovers in a Segment of Chromosome 1B of Bread Wheat (Triticum aestivum L.)
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[5] Ipl1/Aurora Kinase Suppresses S-CDK-Driven Spindle Formation during Prophase I to Ensure Chromosome Integrity during Meiosis
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[6] Origin licensing and p53 status regulate Cdk2 activity during G1
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[7] Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma
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[8] Involvement of p27kip1 and cyclin D3 in the regulation of cdk2 activity during skeletal muscle differentiation
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[9] ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation
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[10] Linker Histones Stimulate HSPA2 ATPase Activity Through NASP Binding and Inhibit CDC2/Cyclin B1 Complex Formation During Meiosis in the Mouse
Alekseev, Oleg M.
Richardson, Richard T.
O'Rand, Michael G.
BIOLOGY OF REPRODUCTION, 2009, 81 (04) : 739 - 748

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