An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway

被引：886

作者：

Schiemann, B ^{[1
]}

Gommerman, JL ^{[1
]}

Vora, K ^{[1
]}

Cachero, TG ^{[1
]}

Shulga-Morskaya, S ^{[1
]}

Dobles, M ^{[1
]}

Frew, E ^{[1
]}

Scott, ML ^{[1
]}

机构：

[1] Biogen Inc, Cambridge, MA 02142 USA

来源：

SCIENCE | 2001年 / 293卷 / 5537期

关键词：

D O I：

10.1126/science.1061964

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The B cell activating factor BAFF (BtyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

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页码：2111 / 2114

页数：4

相关论文

共 34 条

[1] BAFF mediates survival of peripheral immature B lymphocytes [J].

Batten, M ;

Groom, J ;

Cachero, TG ;

Qian, F ;

Schneider, P ;

Tschopp, J ;

Browning, JL ;

Mackay, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1453-1465

[2]

Cheema GS, 2001, ARTHRITIS RHEUM-US, V44, P1313, DOI 10.1002/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO

[3]

2-S

[4] B-1 cell development:: Evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation [J].

Clarke, SH ;

Arnold, LW .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) :1325-1334

[5] Chemokines - Chemokines and cell migration in secondary lymphoid organs [J].

Cyster, JG .

SCIENCE, 1999, 286 (5447) :2098-2102

[6] BCMAP - AN INTEGRAL MEMBRANE-PROTEIN IN THE GOLGI-APPARATUS OF HUMAN MATURE B-LYMPHOCYTES [J].

GRAS, MP ;

LAABI, Y ;

LINARESCRUZ, G ;

BLONDEL, MO ;

RIGAUT, JP ;

BROUET, JC ;

LECA, G ;

HAGUENAUERTSAPIS, R ;

TSAPIS, A .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (07) :1093-1106

[7] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease [J].

Gross, JA ;

Johnston, J ;

Mudri, S ;

Enselman, R ;

Dillon, SR ;

Madden, K ;

Xu, WF ;

Parrish-Novak, J ;

Foster, D ;

Lofton-Day, C ;

Moore, M ;

Littau, A ;

Grossman, A ;

Haugen, H ;

Foley, K ;

Blumberg, H ;

Harrison, K ;

Kindsvogel, W ;

Clegg, CH .

NATURE, 2000, 404 (6781) :995-999

[8] APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth [J].

Hahne, M ;

Kataoka, T ;

Schröter, M ;

Hofmann, K ;

Irmler, M ;

Bodmer, JL ;

Schneider, P ;

Bornard, T ;

Holler, N ;

French, LE ;

Sordat, B ;

Rimoldi, D ;

Tschopp, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (06) :1185-1190

[9] B cell development pathways [J].

Hardy, RR ;

Hayakawa, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :595-621

[10] DISTINCTIVE DEVELOPMENTAL ORIGINS AND SPECIFICITIES OF MURINE CD5(+)B CELLS [J].

HARDY, RR ;

CARMACK, CE ;

LI, YS ;

HAYAKAWA, K .

IMMUNOLOGICAL REVIEWS, 1994, 137 :91-118

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