Overview of Neutralizing Antibodies and Their Potential in COVID-19

被引：48

作者：

Morales-Nunez, Jose Javier ^{[1
]}

Munoz-Valle, Jose Francisco ^{[1
]}

Torres-Hernandez, Paola Carolina ^{[2
]}

Hernandez-Bello, Jorge ^{[1
]}

机构：

[1] Univ Guadalajara, Univ Ctr Hlth Sci CUCS, Inst Res Biomed Sci, Guadalajara 44340, Jalisco, Mexico

[2] Univ Guadalajara, Univ Ctr Hlth Sci CUCS, Immunol Lab, Guadalajara 44340, Jalisco, Mexico

来源：

VACCINES | 2021年 / 9卷 / 12期

关键词：

neutralizing antibodies; SARS-CoV-2; neutralization assays; COVID-19; monoclonal antibodies; MEMORY B-CELLS; DEPENDENT ENHANCEMENT; VIRUS ENTRY; MEDIATED NEUTRALIZATION; MONOCLONAL-ANTIBODIES; AFFINITY MATURATION; SARS-COV-2; SPIKE; MECHANISMS; INFECTION; ASSAY;

D O I：

10.3390/vaccines9121376

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and therapeutic development. Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd immunity against SARS-CoV-2, vaccine efficacy, and humoral protective response longevity, as well as supporting donor selection criteria for convalescent plasma therapy. In the current manuscript, we review the essential concepts of NAbs, examining their concept, mechanisms of action, production, and the techniques used for their detection; as well as presenting an overview of the clinical use of antibodies in COVID-19.

引用

页数：22

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