In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process

被引：69

作者：

Kim, Taik Nam ^{[1
]}

Balakrishnan, A. ^{[1
]}

Lee, B. C. ^{[1
]}

Kim, W. S. ^{[2
]}

Dvorankova, B. ^{[3
,4
,5
]}

Smetana, K. ^{[3
,4
,5
]}

Park, J. K. ^{[6
]}

Panigrahi, B. B. ^{[7
]}

机构：

[1] Paichai Univ, Dept Informat & Elect Mat Engn, Taejon 302735, South Korea

[2] Daejon Hlth Sci Coll, Dept Dent, Lab Technol, Taejon 300711, South Korea

[3] Charles Univ Prague, Fac Med 1, Inst Anat, Prague, Czech Republic

[4] Charles Univ Prague, Fac Med 2, Inst Anat, Prague, Czech Republic

[5] Ctr Cell Therapy & Tissue Repair, Prague, Czech Republic

[6] Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Taejon 305701, South Korea

[7] Korea Res Inst Standards & Sci, Div Adv Technol, Taejon 305340, South Korea

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2008年 / 19卷 / 02期

关键词：

D O I：

10.1007/s10856-007-3204-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The in vitro response of the mouse fibroblast cell line 3T3 on the surface of ultrafine grained titanium [produced by a severe plastic deformation (SPD) process] has been studied in this work. SPD Ti showed much higher strength than the coarse grained Ti and equivalent to that of Ti-6Al-4V alloy. Better cell proliferation was observed on SPD Ti compared to conventional Ti and Ti-6Al-4V alloy. This could be attributed to the increased surface free energy by reduction in the grain size and possibly the presence of a large number of nano size grooves at the triple point junctions in SPD Ti sample. There was no significant difference in the results of cytotoxicity tests of fine and coarse grained materials.

引用

页码：553 / 557

页数：5

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