The signal recognition particle

被引：474
作者：
Keenan, RJ
Freymann, DM
Stroud, RM
Walter, P
机构：
[1] Maxygen, Redwood City, CA 94063 USA
[2] Northwestern Univ, Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA
[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 2001年 / 70卷
关键词：
Alu domain; SRP; SRP54; Ffh; SRP receptor; FtsY; signal sequence; GTPase; SRP9/14; SRP RNA;
D O I：
10.1146/annurev.biochem.70.1.755
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The signal recognition particle (SRP) and its membrane-associated receptor (SR) catalyze targeting of nascent secretory and membrane proteins to the protein translocation apparatus of the cell. Components of the SRP pathway and salient features of the molecular mechanism of SRP-dependent protein targeting are conserved in all three kingdoms of life. Recent advances in the structure determination of a number of key components in the eukaryotic and prokaryotic SRP pathway provide new insight into the molecular basis of SRP function, and they set the stage for future work toward an integrated picture that takes into account the dynamic and contextual properties of this remarkable cellular machine.
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收藏
页码：755 / 775
页数：21
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