Should Abacavir Be a First-Line Alternative for Adults With HIV in Sub-Saharan Africa?

被引：0

作者：

Lee, Guinevere Q. ^{[1
,2
,3
]}

McCluskey, Suzanne ^{[2
,3
]}

Boum, Yap ^{[4
]}

Hunt, Peter W. ^{[5
]}

Martin, Jeffrey N. ^{[6
]}

Bangsberg, David R. ^{[7
]}

Gao, Xiaojiang ^{[8
]}

Harrigan, P. Richard ^{[1
]}

Haberer, Jessica E. ^{[2
]}

Siedner, Mark J. ^{[4
]}

机构：

[1] BC Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[2] Massachusetts Gen Hosp, Dept Infect Dis, Boston, MA 02114 USA

[3] Harvard Med Sch, Harvard Univ Ctr AIDS Res, Boston, MA 02115 USA

[4] Mbarara Univ Sci & Technol, Fac Med, Mbarara, Uganda

[5] Univ Calif San Francisco, HIV AIDS Div, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94143 USA

[7] Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland, OR USA

[8] NCI, Ctr Canc Res, Frederick, MD 21701 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2017年 / 76卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Uganda; Africa; HIV; antiretroviral therapy; HLA-B*57:01; abacavir; INITIATING ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE INHIBITORS; T-CELL RECOVERY; DRUG-RESISTANCE; MYOCARDIAL-INFARCTION; HYPERSENSITIVITY REACTION; NAIVE INDIVIDUALS; CONTROLLED-TRIAL; ZIDOVUDINE; EFAVIRENZ;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite a poor toxicity profile, zidovudine supersedes abacavir (ABC) as an alternative first-line agent in most international treatment guidelines because of concerns about HLA-B*57:01-related ABC-hypersensitivity. We detected one case of HLA-B*57:01 carriage among 513 HIV-infected individuals in Uganda, which, in combination with previous reports, supports the safety of ABC in the region.

引用

页码：188 / 192

页数：5

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